Children with medical complexity often receive a recommendation to see an outpatient clinician soon after leaving the hospital. It is uncertain whether every child needs this routine visit or whether follow-up can be guided by the family's concerns and the child's recovery. AFTERCARE is a multicenter pilot randomized trial comparing these two follow-up recommendations for children hospitalized with an acute infection.
Families will be assigned by chance to receive either a recommendation to arrange follow-up with their usual outpatient clinician within seven days or a recommendation to seek follow-up if the child is not improving as expected or new concerns arise. Families in both groups may seek medical care whenever needed. The study will assess recruitment, follow-up data collection, delivery of the recommendations and acceptability. Caregiver surveys and medical record review will also describe outpatient visits and hospital returns. This pilot will inform the design of a larger trial, and is not designed to establish that the strategies are equally safe or effective.
Children aged 1 to younger than 17 years at hospital admission.
Chronic medical conditions affecting at least two body systems.
Hospitalized on a general pediatric, complex care or equivalent service for a respiratory infection, urinary tract infection, skin or soft-tissue infection, or infectious gastroenteritis.
Expected discharge home, with an adult parent or legal guardian available to provide consent and complete study activities.
Enrollment after hospital day 30.
Primary care follow-up already scheduled or recommended within seven days after discharge, or a strong family or clinician preference that makes randomization unacceptable.
History of cancer or organ, bone marrow or stem-cell transplantation.
A new type of medical equipment needed at home, or planned home intravenous nutrition or antibiotics.
Parallel
Automatic follow-up recommendation
BehavioralFamilies are instructed to arrange follow-up with their usual outpatient clinician within seven days after hospital discharge. This is the clinician or team the family usually contacts first for health concerns and may be a generalist, complex-care clinician or specialist. Other specialist care continues as usual.
As-needed follow-up recommendation
BehavioralFamilies are instructed that follow-up is recommended if the child is not improving as expected or new concerns arise. This recommendation concerns follow-up with the clinician or team the family usually contacts first for health concerns, which may be a generalist, complex-care clinician or specialist. Other specialist care continues as usual.
Eligible hospitalizations per site per month
Number of hospitalizations confirmed as initially eligible through study screening per month that a study site is open to recruitment.
Clinician acceptance rate
Percentage of consented patients with known objection status for whom no clinician objected to randomization, including no reply after clinician notification and the response period.
Family consent rate
Percentage of initially eligible families offered study participation who provide consent.
Difference in seven-day primary care follow-up between study arms
Automatic minus as-needed difference in the percentage of patients with known follow-up status who have a clinical visit or call with their regular doctor or usual care team within seven days after discharge.
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