The aim of the study is to investigate autonomic modulation in terms of heart rate variability (i.e., HRV) in patients undergoing assisted mechanical ventilation in PSV mode, compared to patients assisted in PAV+ mode. The hypothesis is that the greater patient-ventilator synchrony of the latter mode may represent an advantage in reducing the imbalance of autonomic modulation.
Patients admitted to the ICU, ≥18 years old, undergoing invasive controlled mechanical ventilation for at least 72 hours, eligible for assisted support but not yet ready for extubation or spontaneous breathing.
Successful completion of a spontaneous breathing trial (SBT) and spontaneous breathing within 24 hours of enrollment
Acute ischemic heart disease, cardiac rhythm abnormalities, and/or patients with pacemakers and/or treated with anti-arrhythmic drugs
Hemodynamic instability
Chest drainage
Mechanically ventilated ICU patients ready to be weaned
Case-control
Prospective
Heart Rate Variability
Diagnostic testHeart rate variability evaluation through different domains
LF dominion
To evaluate the difference in the LF domain between patients assisted in PSV and those assisted in PAV+ at T1 (30 minutes).
Other domains
To evaluate the difference in other HRV domains between patients assisted in PSV and those assisted in PAV+ at different time points.
Clinical outcomes
Correlation of HRV parameters with days of assisted ventilation and total ventilation, hospital length of stay (H-LOS) and ICU length of stay (ICU-LOS), mortality, organ dysfunction, delirium, supraventricular and ventricular arrhythmias, etc.
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
