We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care.
autonomic neuropathy
Postural orthostatic tachycardia syndrome
hypermobile or classical Ehlers Danlos syndromes
Chronic fatigue syndrome, mast cell activation syndrome and/or PostCOVID
pregnancy
Pacemaker or Deep brain Stimulation
sensory or motor Polyneuropathy
neurodegenerative disease
We will include patients with above mentioned disease who are diagnosed and treated in our outpatient clinic for autonomic disorders in Aachen, Germany.
Case-control
Prospective
No intervention planned, but all patients get our standart treatment
Other interventionPatients are selected from clinical Routine and get our standart Treatment based on their disease
Blood pressure
Change in systolic and diastolic blood pressure over time
Heart frequency
Change in heart frequency over time
Skin biopsy
intraepithelial nerve fiber density between groups
Composite autonomic severity Score
Change of the Score over time, the results are interpreted as normal (score=0), mild (score=1-3), moderate (score=4-6) or severe (score=7-10)
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RWTH Aachen University
Lead sponsor
DLR German Aerospace Center
Collaborator
