Health TrialsbyHealthPanel

AvoCog - the Effect of Daily Avocado Intake on Cognitive Function in Older Adults

ConditionBrain Aging
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-85
SponsorUniversity of Kansas Medical Center

About this trial

The goal of this clinical trial is to determine if adding avocados to the diet of impacts cognition in 70 older adults, age 65-85, without dementia. We will test for change in functional MRI, cognitive performance, and brain blood flow. Intervention group participants will be asked to consume 1 avocado per day for 12 weeks. Participants in the control group will be asked to continue their normal intake for 12 weeks. Throughout the study, participants will be asked to perform cognitive tests, MRI, blood tests, and questionnaires.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Males and females aged 65-85 years

Good general health with no concomitant disease

BMI 18.5 - 35 kg/m2

Mini Mental State Exam ≥26

Disqualifiers

Unwilling or unable to consume avocado

Latex allergy

Consistently taking lutein + zeaxanthin supplements

Skin carotenoid content ≥400

Trial design

Design model

Parallel

Treatments tested in this trial

  • Avocado Group

    Other intervention

    Participants will consume provided avocados daily and track consumption for the duration of the study. Participants will be adding avocados to their diet and will receive education on maintaining usual diet.

Treatment groups

70 Participants
are divided into 2 treatment groups
Group A: Avocado GroupExperimental treatment 1 intervention
Group B: No Diet Modification GroupNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Change in brain activity

MRI will be used to measure changes in brain activity during resting state, a working memory task, and executive function task.

Time frame
Baseline and 12 weeks

Secondary outcomes

1

Changes in cerebral blood flow

MRI will be used to measure change in cerebral blood flow.

Time frame
Baseline and 12 weeks
2

Changes in memory and executive function

NIH Toolbox will be used to measure change in cognition throughout the study.

Time frame
Baseline and 12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Kansas Medical Center

Lead sponsor

Avocado Nutrition Center

Collaborator

Source ClinicalTrials.gov
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