AYAHIV Role-based Responsibilities for Oncology-focused Workforce (ARROW)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age15-39
SponsorImplenomics
About this trial
Adolescents and young adults living with HIV experience higher premature mortality from cancer than their uninfected peers. In Zambia, because of multilevel barriers, interventions for early diagnosis and optimized treatment to reduce this cancer mortality are underutilized for this disproportionally impacted cohort. In this study, the investigators will test peer-to-peer education and support strategies to increase use of early diagnosis services in HIV treatment facilities and improve compliance with cancer treatment in the cancer center.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
15 to 39 years of age at the time of study enrolment, on antiretroviral medication (ART) for at least 6 months and with no pending plans to move from current residence during the 3-year study duration
Disqualifiers
pregnant at study enrolment
Trial design
Design model
Parallel
Treatments tested in this trial
ARROW strategies
Other interventionARROW strategies are peer-to-peer support at the patient, provider and health system levels
One-time education
Other interventionThe comparison group will receive a one-time education campaign that will provide informational brochures to adolescents and young adults living with HIV and HIV providers
Treatment groups
4,100 Participants
are divided into 2 treatment groupsGroup A: ARROW strategiesExperimental treatment 1 intervention
Group B: One-time educationActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Proportion who complete screening/physical examination
Number who complete screening/physician exams
Time frame
12 months after study enrollment2
Proportion who complete recommended cancer treatment modalities
Number who complete treatment
Time frame
12 months after diagnosisSecondary outcomes
1
Proportion who complete recommended follow-up supplemental diagnostic procedures
Number who complete follow-up
Time frame
3 months from receipt of follow-up referral2
Proportion who initiate cancer treatment
Number who initiate treatment
Time frame
3 months from diagnosis3
Proportion alive at 12 months
Number alive at 12 months
Time frame
12 months after diagnosisSponsors and contacts
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Source ClinicalTrials.gov