Bacteria in Dental Plaque and Atheroma Plaque
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-85
SponsorIstanbul Saglik Bilimleri University
About this trial
Periodontitis is considered a focus of infection where oral bacteria, bacterial by-products or inflammatory mediators can interact with other parts of the organism via the blood. Periodontal pathogen components such as DNA, RNA or specific antigens of P. gingivalis, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Treponema denticola (T. denticola), Fusobacterium nucleatum (F. nucleatum) or Campylobacter rectus have been isolated from different tissues such as atheroma plaques, placenta, amniotic sac and respiratory tract. It has been reported that periodontitis may contribute to endothelial dysfunction leading to the formation of atherosclerosis.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diagnosed with endarterectomy
Not receiving chemotherapy
Not having received this treatment before
Disqualifiers
Having systemic infection
Patients with severe heart disease
Trial population
Endearterectomy diagnosed, dentate and edentulous patients
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
atheroma plaque
Other interventionDuring the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.
dental plaque
Other interventionSubgingival plaque samples will be collected from patients before the endarterectomy procedure.
Treatment groups
60 Participants
are divided into 1 treatment groupGroup A: Patients diagnosed with endarterectomy2 interventions
Trial outcomes
Primary outcomes
1
Number of bacteria
Subgingival plaque
Time frame
through study completion, an average of 2 months2
Number of bacteria
atheroma plaque
Time frame
through study completion, an average of 2 monthsSponsors and contacts
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Source ClinicalTrials.gov