Basal LH Threshold for the Diagnosis of Central Precocious Puberty
ConditionPrecocious Puberty, Central
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age4-11
SponsorUniversity Hospital, Strasbourg, France
About this trial
This retrospective monocentric observational study aims to evaluate whether basal luteinizing hormone (LH) levels can reliably diagnose central precocious puberty and reduce the need for LHRH stimulation testing. Currently, all patients with suspected precocious puberty undergo LHRH testing regardless of basal LH levels.
The study will analyze pediatric patients evaluated between 2019 and 2024 to determine an optimal basal LH threshold with high specificity. Secondary analyses will assess diagnostic performance and explore clinical and biological factors influencing LH levels. The results may help reduce unnecessary testing and improve diagnostic strategies.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Children aged 4 to 11 years
Underwent LHRH stimulation testing for suspected precocious puberty between 01/01/2019 and 01/01/2024
No written opposition to reuse of medical data
Disqualifiers
Written opposition to data reuse
Age <4 years or >11 years 11 months
LHRH test performed for indications other than suspected precocious puberty
Trial population
Children evaluated for suspected central precocious puberty in a pediatric day hospital setting, who underwent LHRH stimulation testing.
Trial design
Design model
Case-only
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Basal LH threshold for diagnosis of central precocious puberty
Determination of the basal LH level associated with a positive diagnosis of central precocious puberty (LH peak \>5 IU/L) and estimation of the number of LHRH stimulation tests that could have been avoided using this threshold.
Time frame
At time of diagnostic evaluation (retrospective data from 2019-2024)Sponsors and contacts
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Source ClinicalTrials.gov