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Basilar Artery Occlusion Chinese Endovascular Registry in Patients With Large-Core Infarct

ConditionsBasilar Artery OcclusionIschemic StrokeLarge Core Infarct
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorXuanwu Hospital, Beijing

About this trial

This multicenter retrospective registry study evaluates the safety and effectiveness of endovascular therapy versus medical therapy for acute large-core basilar artery occlusion. It also investigates clinical, imaging, and laboratory factors associated with functional outcomes and mortality. Patients are grouped according to the treatment received in routine clinical practice.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥18 years, men or women.

Occlusion (TIMI 0-1) of the basilar artery or intracranial segments of both vertebral arteries (V4) as evidenced by CTA/MRA/DSA.

Time from symptom onset (or last known well) to treatment (endovascular therapy or medical therapy) ≤7 days.

Patients with large core infarction in the posterior circulation, defined as a posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) score of 0-5 on CT angiography source images or MR with diffusion-weighted imaging or non-contrast CT.

Disqualifiers

Subjects with occlusions in both anterior and posterior circulation.

CT or MR evidence of hemorrhage (the presence of microbleeds on MRI is allowed).

Missing key clinical information (e.g., unavailable baseline NIHSS, unclear symptom onset/last known well time, or missing major treatment information including whether EVT was performed).

Baseline NIHSS score <6.

Trial population

Adults (≥18 years) with imaging-confirmed acute vertebrobasilar occlusion and large-core infarction (pc-ASPECTS 0-5) treated within 7 days of symptom onset/last known well at participating centers in China. Patients are identified retrospectively from routine clinical practice and classified according to treatment received: endovascular therapy plus standard medical management versus standard medical management alone.

Trial design

Design model

Cohort

Time perspective

Retrospective

Treatments tested in this trial

  • Endovascular Therapy

    Procedure/Surgery

    Endovascular therapy performed as part of routine clinical care for acute basilar artery occlusion, including mechanical thrombectomy with stent retriever and/or aspiration. Rescue angioplasty and/or intracranial stenting may be used at the operator's discretion. Peri-procedural management and concomitant medical therapy follow local standard practice.

Treatment groups

518 Participants
are divided into 2 treatment groups
Group A: Endovascular Therapy1 intervention
Group B: Best Medical Treatment Alone0 interventions

Trial outcomes

Primary outcomes

1

Proportion of Patients Achieving mRS 0-3 at 90 Days

The modified Rankin scale (range, 0 \[no symptoms\] to 6 \[death\]). Higher scores mean a worse outcome.

Time frame
90 days

Secondary outcomes

1

Ordinal Shift analysis of mRS at 90 days

The modified Rankin scale (range, 0 \[no symptoms\] to 6 \[death\])

Time frame
90 days
2

Rate of All-Cause Mortality at 90 Days

Death from any cause within 90 days.

Time frame
90 days
3

Rate of Symptomatic Intracranial Hemorrhage

Time frame
24 (-2/+12) hours
4

Proportion of Patients Achieving mRS 0-3 at 1 year

The modified Rankin scale (range, 0 \[no symptoms\] to 6 \[death\]). Higher scores mean a worse outcome.

Time frame
1 year

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Xuanwu Hospital, Beijing

Lead sponsor

Source ClinicalTrials.gov
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