About this trial
Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay. The right ventricle is particularly vulnerable to an increased afterload. By increasing pulmonary vascular resistance (PVR), atelectasis might mitigate a negative effect on the right ventricle.
Recruitment maneuvers have been shown to resolve atelectasis and improve hemodynamics by increasing cardiac output and lowering PVR. However these maneuvers transiently raise airway pressures, which in turn increases right ventricular afterload, a situation often poorly tolerated by patients with RVF.
Prone position is used in patients with respiratory failure and has been shown to decrease mortality in patients with ARDS. Prone position decreases atelectasis and moves ventilation dorsally. In ARDS it also seems to mediate beneficial hemodynamic effects such as an increase in cardiac output and a decrease in PVR.
The investigators hypothesis is that prone position early after cardiac surgery will increase cardiac output by recruitment of atelectasis and thereby decrease PVR.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Scheduled for cardiac surgery using cardiopulmonary bypass
Disqualifiers
BMI >40
Emergency surgery
Advanced grown-up congenital heart disease
Severe pulmonary disease
Trial design
Parallel
Treatments tested in this trial
Prone position
Procedure/SurgeryProne position is applied in the intervention group immediately after randomization, patients will be prone for a total of 2 hours and 15 minutes. During this time 3 data collection points occur (t1, t2 \& t3).
Treatment groups
Trial outcomes
Primary outcomes
Cardiac Index
L/min/m2
Secondary outcomes
PVRi
Difference between and within groups
Cardiac Index
Difference between and within groups
RV pressure
Looking at differences of right ventricular blood pressure between groups at all timepoints
Driving Pressure
Plateau Pressure - PEEP
Other outcomes
RV contractility during recruitment maneuver
Measured as dP/dt (mmHg/s). Maximum upslope of the pressure waveform measured at the RV.
Physiological dead space
Eventual exploratory outcome. Analysis of VD/VT using Enghoff-modified Bohr equations.
Subgroup analysis of Cardiac Index
Patients with perioperative or postoperative diagnosed RVF according to a published standardized definition will be analyzed separately in a subgroup analysis.
Subgroup analysis of PVRi
Patients with perioperative or postoperative diagnosed RVF according to a published standardized definition will be analyzed separately in a subgroup analysis.
Sponsors and contacts
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