Bern Intracoronary Optical Coherence Tomography and Coronary Computed Tomography Angiography Registry (BIOCORE) is a systematic institutional registry on patients undergoing paired CCTA and OCT for validation and development of advanced methods to determine coronary plaque morphology, lesion severity, PCI guidance, and it association with long-term clinical outcomes.
≥18 years of age
Written informed consent
CCTA within 3 months from invasive coronary angiography and OCT
At least one vessel with ≥50% diameter stenosis on CCTA
CCTA performed more than 3 months from OCT
Poor OCT quality
Poor CCTA quality
Coronary anomalies
Patients undergoing CCTA and invasive coronary angiography with OCT in native coronary vessels within 3 months
Cohort
Prospective
Not listed
Diagnostic accuracy in plaque phenotyping CCTA vs. OCT
Proportion of correctly classified plaques quantitative computed tomography (QCT) (low-attenuation, non-calcified, calcified plaques) against the gold standard OCT (lipid-rich, fibrous, fibro-calcific plaque)
PCI planning with CCTA vs. gold standard OCT
Diagnostic accuracy of CCTA in identifying the need for PCI and agreement in stent sizing
Photon-counting vs. conventional CCTA
Proportion of correctly classified plaques with photon-counting CCTA vs. conventional CCTA (low-attenuation, non-calcified, calcified plaques) against the gold standard OCT for plaque morphology (lipid-rich, fibrous, fibro-calcific plaque)
Clinical outcomes throughout 1 and 5 years
* All-cause death * Cardiovascular death * Myocardial infarction * Unstable angina pectoris * Clinically-driven coronary revascularization * Stent thrombosis * In-stent-restenosis
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