All living things are made of building blocks called cells. Genes are the part of cells that contain the instructions which determine important things about you, like your height or hair color, and affect your health. DNA is the material in the cells that makes up your genes and your particular make-up is call your genotype. Changes or differences in a gene (your genotype) may affect your chances of developing a particular disease, or how a person responds to a particular drug. Your genes are passed down from your parents and then passed on to your children. Different forms of certain genes in your body, for example, the B2AR gene, can increase your blood pressure. The form of the gene that could raise your blood pressure is called the risk allele or risk genotype.
Taking too much salt in your food or drink also can increase your blood pressure. In this research study we want to determine if different forms of the B2AR gene and the level of salt intake act together to cause high blood pressure.
Ages 18-50 years; HTN as defined by the primary physician; on ≤ two anti-hypertensives; normal renal, liver, metabolic, electrolyte, CBC, and thyroid tests.
Pregnancy; renal, neurologic, and cardiac diseases other than HTN; diabetes; secondary HTN as assessed by history, physical examination, screening blood and urine tests; any drug therapy, except for anti-hypertensives and replacement thyroid medication; and no oral contraceptives/implants/ERT within 2 years of study.
Crossover
low sodium diet
Other interventionLow Sodium Diet
high sodium diet
Other interventionHigh Sodium Diet
renal plasma flow
Procedure/Surgeryrenal blood flow response to diet and angiotensin II by diplotype
SIEA collection
Procedure/SurgeryVasoreactivity response by diplotype
Differences in systolic SSBP between the diplotypes
Differences in systolic SSBP between the diplotypes
Differences in B2AR expression levels by diplotype
Differences in B2AR expression levels by diplotype
Sodium excretion response to acute sodium load by diplotype
Sodium excretion response to acute sodium load by diplotype
Click on the lead sponsor to view all of their trials.
Brigham and Women's Hospital
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
