This single-center, prospective, controlled trial compares betacyanin versus conventional methods for early diagnosis and healing assessment of anastomotic leakage after rectal cancer surgery.
Pathologically confirmed rectal adenocarcinoma prior to surgery.
Undergoing laparoscopic anterior resection for rectal cancer.
No prophylactic diverting ileostomy.
American Society of Anesthesiologists (ASA) Physical Status Classification ≤ 3.
Prior abdominal surgery with severe intra-abdominal adhesions.
Currently participating in, or having participated within the past 6 months in, another clinical study related to rectal cancer surgery.
Preoperative complications requiring emergency surgery, including bleeding, perforation, or obstruction.
History of prior malignancy.
Single group
Betacyanin
Dietary supplement200 mL oral betacyanin solution administered daily from postoperative day 3 until discharge or confirmation of anastomotic leakage
Pelvic Drainage Fluid Betacyanin Assay
Diagnostic testDaily measurement of betacyanin concentration in pelvic drainage fluid for early detection of anastomotic leakage
Time to Diagnosis of Anastomotic Leakage
Diagnostic Performance of Betacyanin for Anastomotic Leakage
Time to Healing of Anastomotic Leakage
Incidence of Postoperative Grade III-IV Complications
Reoperation Rate
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