Bicarbonate HD Study
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorEast and North Hertfordshire NHS Trust
About this trial
The primary goal of this single centre observational study is to look at factors that affect serum bicarbonate levels in patients on maintenance dialysis. This will be done by collecting demographic information, relevant medical history, dialysis history, potential renal acid load from diet by recording different foods consumed over 2 days in a food diary and bicarbonate levels at 3 intervals, pre and post dialysis session 1 and pre dialysis session 2.
Bicarbonate levels are of significant interest as an indicator of metabolic acidosis in CKD dialysis patients. This study will allow us to understand the efficacy of different dialysis modalities in controlling bicarbonate levels. It will also enable us to understand the idea of individualizing dialysis for patients in terms of not using a standard concentration of dialysate for all patient undergoing dialysis in this center.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18 years and above.
Ability to give informed consent.
End Stage Renal Disease established on maintenance dialysis for at least 3 months.
Patients on dialysis 3 times a week
Disqualifiers
Inability to give informed consent
Patients with acute kidney injury
Patients with severe COPD
Trial population
The study population will consist of adult patients with End Stage Renal Disease (ESRD) receiving maintenance dialysis at the study centre.
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Change in serum bicarbonate levels in patients on haemodialysis
Serum bicarbonate concentration measured across two dialysis sessions (HD1 and HD2) measured as Pre HD1, Post HD2 and Pre HD2.
Time frame
3 monthsSecondary outcomes
1
Dietary Acid Load
Potential renal acid load
Time frame
~ 3 months2
Volume of Haemodiafiltration
Haemodiafiltration volume delivered
Time frame
3 months3
Indicators of dialysis dose
Pre HD1 and Post HD1 serum urea
Time frame
3 monthsSponsors and contacts
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Source ClinicalTrials.gov