BID LTM Digital Intervention in Aging
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-85
SponsorUniversity of California, San Francisco
About this trial
Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM). The decline in these faculties is accelerated and becomes significant deficits in LTM and cognitive control functions at the level or a diagnosis of Mild Cognitive Impairment (MCI). Training with the navigation game, relative to training with control games, is expected to improve LTM performance for older adult participants.
Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function.
Participants will conduct study activities remotely (e.g., at-home):
1. Baseline Assessment. Complete a series of cognitive assessments and surveys. 2. Intervention. Engage in a digital intervention for up to 8 weeks. 3. Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment. 4. Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Minimum of 12 years of education
English fluency: All task instructions are presented in English language text. In order to control for sufficient and equivalent participant comprehension of the procedures and instructions, we require their self-report of fluency in English.
Normal or corrected-to-normal vision
Normal or corrected-to-normal hearing
Disqualifiers
Under the age of 60
Clinical diagnosis of neurological or psychiatric disorder Clinical diagnosis of dementia or AD8 score of >4
Visually or hearing impaired without correction to normal
Regularly (one or more times per week) practicing an instrument within the last year
Trial design
Design model
Parallel
Treatments tested in this trial
Long Term Memory
BehavioralTablet computer game designed to stimulate environmental enrichment via an adaptive and immersive experience learning virtual neighborhoods and errands in order to complete assigned errands.
Worder
BehavioralTablet computer game designed to stimulate interest in solving word puzzles, much like the Boggle game.
Treatment groups
150 Participants
are divided into 2 treatment groupsGroup A: Long Term MemoryActive comparator 1 intervention
Group B: WorderActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
MDT change in recognition memory
Psychometric test for proportion correct in memory for studied images of common objects versus paired similar lures
Time frame
baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests2
TOUR change in cued recall memory
Psychometric test for proportion of details correctly recalled from recent autobiographical memory
Time frame
baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training testsSecondary outcomes
1
Cognitive Assessment change in working memory
Psychometric test for proportion of number of correctly identified images from working memory span
Time frame
baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training testsSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of California, San Francisco
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov