Bimanual Motor Skill Learning in Acute Stroke
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-90
SponsorUniversity Hospital of Mont-Godinne
About this trial
The subacute phase of stroke provides a window into how a lesion perturbs sensorimotor functions prior to reorganisation driven by plasticity and neurorehabilitation. The recovery from motor impairment has been extensively studied, but it is currently unknown whether motor skill learning (MSkL) is enhanced or impaired during acute stroke, especially bimanual motor skill learning (bim-MSkL), which likely requires more motor-attentional-cognitive resources than unimanual MSkL.
The goals of this project are: to determine the neural substrates critical to achieve proximal and distal bimanual motor skill learning (bim-MSkL) by specifying whether (sub)acute stroke to different brain areas (cortical and subcortical) induce specific deficits in bimanual and/or distal bim-MSkL, which behavioral components are involved in bim-MSkL, and whether damage to the motor, sensory and inter-hemispheric pathways specifically impairs proximal and/or distal bim-MSkL.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
acute stroke (< 21 days)
aged 18-90 years
with a demonstrated stroke (ischemic or hemorrhagic) lesion on brain imaging
Disqualifiers
" classical " contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophobia, etc ...)
difficulty in understanding or executing commands
drug/alcohol abuse
severe aphasia / cognitive deficits interfering with study
Trial design
Design model
Parallel
Treatments tested in this trial
REAplan®
Devicemotor skill learning with the REAplan® rehabilitation robot, to be performed with both arms
Dextrain Manipulandum®
Devicemotor skill learning with the Dextrain Manipulandum® dexterity tool to be performed with both hands
Treatment groups
160 Participants
are divided into 2 treatment groupsGroup A: Bimanual Circuit version 1Experimental treatment 2 interventions
Group B: Bimanual Circuit version 2Experimental treatment 2 interventions
Trial outcomes
Primary outcomes
1
bimanual Speed/Accuracy Trade-off (bi-SAT), bimanual Speed/Accuracy Trade-off measured by the REAplan® robot
bimanual Speed/Accuracy Trade-off: mathematical computation of the relationship between speed and accuracy
Time frame
change between baseline (Day 1) and after training (Day 3)2
bimanual Coordination factor (bi-CO), bimanual Coordination factor measured by the REAplan® robot
bimanual Coordination factor, mathematical measure of the phase coherence between speeds of both arms
Time frame
change between baseline (Day 1) and after training (Day 3)3
bi-Force, bimanual force measured by the REAplan® robot
bimanual forces, forces exerted in the wrong direction by each arm (Newtons)
Time frame
change between baseline (Day 1) and after training (Day 3)4
Root Mean Square Error (RMSE), bimanual root mean square error measured by the Dextrain Manipulandum
Tracking error between the actual applied force and the target force
Time frame
change between baseline (Day 1) and after training (Day 3)Secondary outcomes
1
Reaction time measured by the Dextrain Manipulandum
time between the target appearance and when the force applied exceeds threshold
Time frame
change between baseline (Day 1) and after training (Day 3)2
Rise time measured by the Dextrain Manipulandum
time between the reaction time and reaching the plateau
Time frame
change between baseline (Day 1) and after training (Day 3)3
Coactivation measured by the Dextrain Manipulandum
binary measure of unasked fingers activated above the force threshold
Time frame
change between baseline (Day 1) and after training (Day 3)4
Hold time measured by the Dextrain Manipulandum
time of plateau maintenance
Time frame
change between baseline (Day 1) and after training (Day 3)Sponsors and contacts
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Source ClinicalTrials.gov