Health TrialsbyHealthPanel

Biobank for "Arrhythmia and Conduction Disorders: TowArd Pathophysiology Based Treatment"

ConditionsArrythmiaConduction DisorderPathophysiology
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

About this trial

The 'ADAPT' Biobank is a collection of body material and data from patients with or at risk of cardiac arrhythmias who underwent or will undergo (non-) invasive treatment for this disease. Its main objective is to obtain a comprehensive collection of patient information and material to facilitate research and gain better insight into the complex pathophysiology of the different arrhythmias, the multifactorial process, the heterogeneity in clinical presentation, and prognosis.

Bodily material is used for biochemical marker assessments, histological and molecular analyses for research in cardiac arrhythmias.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients visiting the AMC outpatient clinic

MARK AF

INDICO AF

PREDICT AF

Disqualifiers

Age < 18

Unable or unwilling to comply with study procedures

Pregnancy or of childbearing potential without adequate contraception

NYHA class IV heart failure symptoms or left ventricular ejection fraction <35%.

Trial population

Patients diagnosed with cardiac arrhythmia and are treated in the AMC Heart Center are eligible to donate blood or other bodily material for the 'ADAPT' Biobank. Patient are asked to participate in the 'ADAPT' Biobank during outpatient clinic visits or prior to treatment for their arrhythmia.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Biobank for Left atrial appendage tissue

    Other intervention

    Bodily material is used for biochemical marker assessments, histological and molecular analyses for research in cardiac arrhythmias.

  • Biobank for Blood

    Other intervention

    Bodily material is used for biochemical marker assessments, histological and molecular analyses for research in cardiac arrhythmias.

  • Biobank for One or more of following fat patches: epicardial fat, subcutaneous fat, pericardial fat, visceral fat.

    Other intervention

    Bodily material is used for biochemical marker assessments, histological and molecular analyses for research in cardiac arrhythmias.

Treatment groups

1,000 Participants
are divided into 7 treatment groups

7

Treatment groups

See each treatment group below.

Group A: MARK_AF3 interventions
Group B: INDICO AF1 intervention
Group C: PREDICT AF3 interventions
Group D: WEIGHTLOSS AF2 interventions
Group E: MAD AF1 intervention
Group F: Adapt Biobank - AF surgery3 interventions
Group G: Adapt Biobank - blood1 intervention

Trial outcomes

Primary outcomes

1

(new onset) atrial fibrilation

obtain a comprehensive collection of patient information and material to facilitate research and gain better insight into the complex pathophysiology of the different arrhythmias

Time frame
5 year follow up
2

recurrence of cardia arrythmia

obtain a comprehensive collection of patient information and material to facilitate research and gain better insight into the complex pathophysiology of the different arrhythmias

Time frame
5 year follow up

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Lead sponsor

Source ClinicalTrials.gov
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