Health TrialsbyHealthPanel

Biocollection on Peripheral Inflammation

ConditionsSchizoaffective Disorder, Depressive TypeBipolar Disorder IBipolar Disorder II
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorNantes University Hospital

About this trial

Most psychiatric research is based on the nosographic classifications used in current practice. At present, there is no diagnostic or prognostic biomarker for psychiatric pathologies commonly used in clinical practice. The study hypothesis is that peripheral inflammatory biomarkers could be common to several psychiatric disorders, in particular psychotic disorders (bipolar disorder, schizophreniform disorder, schizophrenia, depressive episode with psychotic features). The aim of this project is to set up a bio-collection of biological samples (peripheral blood samples) with associated phenotypic data (assessment of various symptoms using standardized scales in patients whose blood is sampled). The setting up of this cohort follows on from work carried out on a PsyCourse cohort also using a transdiagnostic approach in psychiatry, in order to be able to collaborate within a European research project.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Major patient

Characterized depressive episode with psychotic features,

Bipolar disorder type I

Bipolar disorder type II

Disqualifiers

Pregnant,

History of cancer in the last 5 years,

Vaccination within the last 4 weeks,

Acute or chronic infection,

Trial population

Participants will be recruited through the doctors who care for them on a regular medical basis, during a consultation or hospitalization in a psychiatric unit. After inclusion, an additional blood sample (4 tubes with a peripheral venous sample) will be taken by nurses from the psychiatric wards caring for the patient, during a blood sample taken as part of the patient's care. The sample will be transported to the Biological Resource Center (CRB) at Nantes University Hospital, where it will be stored along with all other study samples.

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

  • Peripheral venipuncture blood sampling, as part of standard care procedures

    Biological/Vaccine

    Collection of 36 mL of blood

  • Interview with a psychiatrist

    Other intervention

    Research project data collection

Treatment groups

50 Participants
are divided into 1 treatment group
Group A: IBIS-PSY patients2 interventions

Trial outcomes

Primary outcomes

1

Demonstration of the presence of diagnostic biomarkers and biomarkers of severity common to several psychiatric disorders.

Biological analysis of IBIS-PSY biocollection samples

Time frame
2 hours

Secondary outcomes

1

Validation of a patient clustering method separating patients with severe symptoms from those with mild symptoms

Time frame
2 hours
2

Replication of a pan-transcriptomic study (A Transcriptome-Wide Association Study (TWAS))

Time frame
2 hours
3

Comparison of biomarkers between different psychiatric illnesses in order to develop models based on biological data that can help the physician adjust the diagnosis

Time frame
2 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Nantes University Hospital

Lead sponsor

CR2TI, INSERM, UMR1064

Collaborator

Source ClinicalTrials.gov
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