Biology of Cerebral Arteriovenous Malformations and Prognosis of Cerebral Arteriovenous Malformations

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age0+
SponsorFondation Ophtalmologique Adolphe de Rothschild

About this trial

The cerebral arteriovenous malformations correspond to the formation of an entanglement of morphologically abnormal vessels called nidus, which shunt the blood circulation directly from the arterial circulation to the venous circulation.

The cerebral arteriovenous malformations are an important cause of hemorrhagic stroke.

The hypothesis is that cerebral haemorrhage associated with a cerebral arteriovenous malformations would come from peri-nidal micro-vessels, in connection with infiltration of leucocytes and / or defective maintenance of microvascular integrity by platelets.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patient over 18 years old

Patient with a cerebral AVM for which an intervention (endovascular treatment or surgery) or only clinical monitoring

Express consent to participate in the study

children

Disqualifiers

Patient benefiting from a legal protection measure

Pregnant or breast feeding woman

Trial population

Patient with a cerebral arterioveinus malformation for which an intervention (endovascular treatment or surgery) or only clinical monitoring is planned

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Associaton between dosage of endothelial marker and the arteriovenous malformation pronostic

associaton between dosage of endothelial marker in blood samples and correlation with clinical outcome

Time frame
6 months
2

Associaton between dosage of platelet and the arteriovenous malformation pronostic

Dosage of platelet in blood samples and correlation with clinical outcome

Time frame
6 months
3

Associaton between dosage of neutrophilic and the arteriovenous malformation pronostic

Dosage of neutrophilic in blood samples and correlation with clinical outcome

Time frame
6 months
4

Associaton between neo-angiogenesis activation markers and the arteriovenous malformation pronostic

Dosage neo-angiogenesis activation markers in blood samples and correlation with clinical outcome

Time frame
6 months

Secondary outcomes

Other outcomes

Sponsors and contacts

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