Biomarkers for Cancer Treatment
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Hospitals Coventry and Warwickshire NHS Trust
About this trial
Circulating biomarkers, such as miRNAs and proteomics, undergo identifiable and measurable changes during and following treatment for cancer, compared to pre-treatment baseline. Some of these changes may be associated either with known treatment parameters or predictive for cardiac or lung toxicity.
The aim is to identify and validate changes following treatment for cancer, compared to pre-treatment baseline, as well as differential miRNA expression in two-group comparisons (patients receiving radical RT/chemoRT for thoracic cancers versus IO-based complex SACT).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patients (Age >18 years)
Histologically/Cytological confirmed solid tumour
Treated with radical RT or concurrent chemo-RT (Cohort 1) OR
Treated with chemo-IO or IO-IO combination (Cohort 2)
Disqualifiers
Contraindication for RT or chemotherapy (Cohort 1) OR
Contraindication for chemotherapy or IO (Cohort 2)
Use of chemotherapy or immunotherapy in the last 5 years. (Cohort 1) OR
Use of radical RT or chemo-RT within the thorax in the last 5 years. (Cohort 2)
Trial population
Patients on treatment for cancer at UHCW NHS Trust
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
48 Participants
are grouped into 2 trial groupsGroup A: Patients treated with RT
Group B: Patients treated with SACT
Trial outcomes
Primary outcomes
1
Blood results
Identifying and validating changes in miRNA expression
Time frame
Baseline visit2
Blood results
Identifying and validating changes in miRNA expression
Time frame
12 week follow-up visitSecondary outcomes
1
Blood results
Identifying and validating changes in protein biomarker profiles
Time frame
Baseline visit2
Blood results
Identifying and validating changes in protein biomarker profiles
Time frame
12 week follow-up visitSponsors and contacts
Click on the lead sponsor to view all of their trials.
University Hospitals Coventry and Warwickshire NHS Trust
Lead sponsor
Coventry University
Collaborator
Source ClinicalTrials.gov