RATIONALE: Studying samples of sputum and tissue in the laboratory from patients with dysplasia or cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help the study of cancer in the future.
PURPOSE: This laboratory study is looking at biomarkers in patients with respiratory tract dysplasia or lung cancer, head and neck cancer, or aerodigestive tract cancer.
Diagnosis of extensive and severe dysplasia of the respiratory epithelium
Those without dysplasia of the respiratory epithelium
Recruited from the SPORE Tissue Procurement Screening Project or by private or academic physicians (for patients with moderate or severe dysplasia)
Survived 1 or more aerodigestive system carcinoma for ≥ 1 year
None
High Risk for Lung Cancer, suspected lung cancer, lung cancer.
Other
Prospective
immunohistochemistry staining method
Other interventionLaboratory test
laboratory biomarker analysis
Other interventionLaboratory Test
sputum cytology
Other interventionLaboratory Test
biopsy
Procedure/SurgeryLaboratory Test
Genetic mutations or altered growth factor expression
Establishment of a tissue repository of normal and dysplastic respiratory epithelium
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University of Colorado, Denver
Lead sponsor
National Cancer Institute (NCI)
Collaborator
