This clinical trial evaluates the impact of blessing stem cell products before infusion on spiritual well-being and quality of life for patients undergoing hematopoietic stem cell transplantation. Stem cell transplantation represents a transformative medical and personal journey for patients and families. For stem cell transplantation (SCT) recipients, higher levels of spiritual well-being correlate with reduced anxiety and depression, greater hope, and improved emotional stability. Because quality of life often declines after SCT, spiritual support becomes crucial. This trial uses a culturally adaptable, standardized blessing that is personalized to align with each patient's faith tradition or personal belief system that may improve spiritual well-being and quality of life for patients undergoing hematopoietic stem cell transplantation.
Adults (≥ 18 years) undergoing autologous or allogeneic SCT
English proficiency (verbal and written)
Willing to engage in spiritual care discussions
Patients opting to have blessings performed privately (non-study chaplain)
Cognitive impairment or psychiatric instability
Pregnant individuals - this exclusion is not related to the blessing intervention but reflects the fact that pregnant individuals are not eligible for SCT under standard oncology transplant protocols due to the high-dose chemotherapy and potential teratogenic effects
Single group
Electronic Health Record Review
Other interventionAncillary studies
Spiritual Therapy
Procedure/SurgeryComplete pre-transplant discussion
Spiritual Therapy
Procedure/SurgeryReceive spiritual blessing of stem cells
Survey Administration
Other interventionAncillary studies
Quality of life
Assessed using Functional Assessment of Cancer Therapy-Bone Marrow Transplant. Will be compared between intervention and control groups over time using repeated-measures analysis of variance (ANOVA) or linear mixed effects models, with group × time interaction terms.
Spiritual support
Assessed via Functional Assessment of Chronic Illness Therapy - Spiritual Well-Being and Brief Multidimensional Measure of Religiousness/Spirituality. Compared between intervention and control groups over time using repeated-measures ANOVA or linear mixed effects models, with group × time interaction terms.
Time to neutrophil engraftment
Will be compared between the intervention and control group using independent t-tests or Mann-Whitney U tests.
Time to platelet engraftment
Will be compared between the intervention and control group using independent t-tests or Mann-Whitney U tests.
Infusion reactions
Will summarize using frequency and proportions, and compare between the intervention and control group using chi-square or Fisher's exact tests.
Infection
Will summarize using frequency and proportions, and compare between the intervention and control group using chi-square or Fisher's exact tests.
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This trial is not recruiting at the moment. You can still explore other options:
