Blood DdPCR for Early Identification and Dynamic Surveillance of Pathogenic Bacteria in ICU Septic Patients: a Single-centre, Prospective, Observational Study

ConditionsSepsis Bloodstream Infections Critically Ill Intensive Care Unit Patients

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology

About this trial

The purpose of this study is to investigate the efficacy of droplet digital PCR (ddPCR) in identifying pathogenic organisms in ICU sepsis patients, aiming to find a method that allows early identification of pathogenic organisms and dynamic surveillance in order to assess the association between pathogenic species and loads and clinical characteristics and outcomes.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients with first diagnosis of sepsis after ICU admission

Disqualifiers

Age under 18 years

Do not meet Sepsis 3.0 diagnostic criteria

Refusal to sign informed consent

Trial population

Patients admitted to ICU

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

60 Participants

are grouped into 1 trial group

Group A: ddPCR group

Trial outcomes

Primary outcomes

Nucleic acid load of pathogenic bacteria at different time points

Time frame

''Nucleic acid load of pathogenic bacteria in the blood versus time'' could have a time frame of ''0, 2-3, 4-5, 6-7, 8-9, 10-12, 13-15, 20-22, 28-30 days post admission to the ICU with the first diagnosis of sepsis''.

Secondary outcomes

28-day mortality

Time frame

Survival status at 28 days after the first diagnosis of sepsis on admission to the ICU

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Lead sponsor

Source ClinicalTrials.gov

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