Health TrialsbyHealthPanel

Bone Microstructure by Using HR-pQCT After Esophagectomy

ConditionsOsteoporosisSarcopeniaEsophageal Cancer
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexMale
Age50-90
SponsorNagasaki University

About this trial

Esophagectomy is most curative treatment to esophageal cancer. However, osteoporosis , which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after surgery. The aim of the present study was to evaluate osteoporosis by using high-resolution peripheral quantitative computed tomography (HR-pQCT) in the long course after esophagectomy. At least 3 years should have elapsed since operation without recurrence of esophageal cancer.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

At least 3 years have elapsed since esophagectomy due to esophageal cancer

Provide signed informed consent

Disqualifiers

Current use of the following osteoporosis agents; Teriparatide, Denosumab, and - -

bisphosphonate

Present malignancy (except in situ carcinoma)

Radiotherapy

Trial population

Japanese

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • esophagectomy

    Procedure/Surgery

    esophagectomy

Treatment groups

118 Participants
are divided into 2 treatment groups
Group A: Esophagectomy1 intervention
Group B: Healthy Control0 interventions

Trial outcomes

Primary outcomes

1

Comparing bone microstructure in control and Esophagectomy groups

volumetric bone mineral density

Time frame
1day

Secondary outcomes

1

Comparing bone microstructure with serum biomarkers of osteoporosis

Correlation between bone mineral density in esophagectomy and biomarkers (25-hydroxyvitaminD, calcium, iPTH, P1NP, ICTP, TRACP5b)

Time frame
1day
2

Comparing bone microstructure with dual-energy X-ray absorptiometry

Correlation of bone mineral density between esophagectomy and DXA

Time frame
1day

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Nagasaki University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: