Bone Regeneration Using PRF After Cyst Enucleation

ConditionsOdontogenic Cyst Jaw Cysts Osseous Defect After Cyst Enucleation

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-80

SponsorSana'a University

About this trial

This randomized controlled clinical trial aims to evaluate the clinical efficacy of autologous platelet-rich fibrin (PRF) in promoting osseous regeneration following cystic enucleation in the jaws. The study will assess bone healing outcomes and compare PRF application with conventional management methods.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients diagnosed with odontogenic cysts requiring surgical enucleation.

Presence of a postoperative osseous defect in the jaws after cyst enucleation.

Age ≥ 18 years.

Systemically healthy patients (ASA I or II).

Disqualifiers

Patients with systemic diseases affecting bone healing (e.g., uncontrolled diabetes, osteoporosis).

Patients receiving bisphosphonates or long-term corticosteroid therapy.

Smokers (>10 cigarettes/day).

Pregnant or lactating women.

Trial design

Design model

Parallel

Treatments tested in this trial

Autologous Platelet-Rich Fibrin (PRF)
Biological/Vaccine
Autologous platelet-rich fibrin (PRF) prepared from the participant's own venous blood will be placed into the osseous defect immediately after cystic enucleation. PRF will be prepared using standard centrifugation protocols and applied to promote bone regeneration.
Conventional Surgical Management
Procedure/Surgery
Conventional cystic enucleation will be performed without the use of platelet-rich fibrin (PRF). The osseous defect will be managed according to standard surgical protocol and allowed to heal naturally.

Treatment groups

20 Participants

are divided into 2 treatment groups

Group A: PRF GroupExperimental treatment 1 intervention

Group B: Control GroupActive comparator 1 intervention

Trial outcomes

Primary outcomes

Radiographic bone regeneration in cystic defects following enucleation

The amount of bone regeneration will be evaluated radiographically using CBCT imaging to measure the percentage of defect fill and bone density changes at 6 months postoperatively.

Time frame

6 months after surgery

Locations

Map coordinates are unavailable for these locations. Locations are shown below instead.

Faculty of Medicine and Health Sciences - Sana'a UniversityRecruiting00000, Sanaa, Sanaa Governorate Yemen

Yemen

Sponsors and contacts

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Sana'a University

Lead sponsor

Source ClinicalTrials.gov

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