About this trial
This cross-sectional observational study aims to evaluate the relationship between boron levels and oxidative stress, antioxidant defense, and inflammatory markers in individuals with periodontitis. The study will include systemically healthy, non-smoking individuals divided into two groups: periodontally healthy controls and patients with Stage III-IV periodontitis. Boron levels and selected oxidative stress, antioxidant, and inflammatory biomarkers will be evaluated in saliva and gingival tissue samples. The findings will be compared between the groups to investigate the potential relationship between boron levels and periodontal inflammation and oxidative stress.
Eligibility criteria
Qualifiers
Volunteering to participate in the study and signing the informed consent form
Being between 18 and 65 years of age
Being systemically healthy
No antibiotic use within the last 3 months
Disqualifiers
Incomplete or unreliable clinical measurements
Insufficient saliva or gingival tissue sample for biochemical analyses
Regular use of boron-containing oral care products within the last 3 months
Regular consumption of boron-rich supplements or mineral waters
Trial design
Treatments tested in this trial
- Biochemical Assessment of Saliva and Gingival Tissue