Health TrialsbyHealthPanel

Brain and Behavior Influences on Obesity Development From Infancy Through Childhood

ConditionObesity and Overweight
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age7-12
SponsorJohns Hopkins University

About this trial

The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function. This data is collected in a sub-sample of RESONANCE, a large study of families of children from infancy through childhood. The results will lay foundations for the development of early interventions to prevent or treat obesity.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Participants from the RESONANCE cohort are eligible if the participant will reach 7-12 years of age during the proposed project period and have no food allergies.

Disqualifiers

In utero exposure to alcohol, cigarette, or illicit substances;

First trimester fetal US abnormalities;

Complicated pregnancy (e.g., pre-eclampsia);

Complicated delivery, including APGAR scores less than 8 and/or neonatal intensive care unit (NICU) admission;

Trial design

Design model

Single group

Treatments tested in this trial

  • fMRI cue reactivity task

    Other intervention

    Measures effect of food and non-food cues on brain activation

  • fMRI go no go task

    Other intervention

    Measures effect of food and non-food cues on inhibitory responses and brain activation

  • Ad libitum meal test

    Other intervention

    Measures effect of exposure to multi-item buffet meal on food intake

  • Eating in the absence of hunger test

    Other intervention

    Measures effect of exposure to palatable snacks on food intake

Treatment groups

210 Participants
are divided into 1 treatment group
Group A: Single armOther 4 interventions

Trial outcomes

Primary outcomes

1

Meal test intake as assessed by total kilocalories consumed

Total kilocalories consumed. Once at the first study visit (lab visit)

Time frame
Day 1
2

Weight/adiposity as assessed by BMI

Body Mass Index z-score. Once at the first study visit (lab visit)

Time frame
Day 1
3

Food-related reward as assessed by food-related delay discounting task

Number of trials the child passes. Once, at the first study visit (lab visit)

Time frame
Day 1
4

Food-related cognitive control as assessed by food-related go/no-go task

Commission error rate. Once, at the first study visit (lab visit)

Time frame
Day 1

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Johns Hopkins University

Lead sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator

Rhode Island Hospital

Collaborator

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Collaborator

University of Washington

Collaborator

Source ClinicalTrials.gov
Apply now