About this trial
Primary muscle tension dysphonia voice disorder with symptoms of vocal strain and vocal fatigue is common and can have a significant negative impact on quality of Life. Yet, primary muscle tension dysphonia's causes are unknown precluding precise diagnostic classification. Stress and personality are thought to play a role and thus, the project aims to determine the practical and clinical effect of stress on the control of voice and speech in the brain. Participants are female early career teachers and student teachers with symptoms of vocal fatigue, as well as control participants without vocal fatigue, who perform speech tasks on two different occasions. Neural (imaging of brain), psychobiological (saliva, personality), and voice and speech (muscle activity of voice muscles on the neck with surface sensors, audio recordings) data will compare reactivity patterns of teachers who are stressresponders with those who are nonresponders as well as control participants. The central hypothesis is that voice box stress responders have heightened emotion-motor activations involving the emotional voice production pathway, which correlate with changes in voice muscle activity in the anterior neck. The results will provide fundamentally missing data in our understanding of the role of stress in vocal complaints and will yield new insights about the neural underpinnings of primary muscle tension dysphonia. The study findings will have a significant impact on how clinicians identify so-called laryngoresponders to help them prevent voice disorders.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
Lefthandedness
Smoking (past 5 years)
Known changes of the vocal folds (e.g., vocal fold nodules), vocal fold paralysis, surgeries on the larynx or thryoid or current organic or neurological changes of the vocal folds or vocal function per videoendoscopy and -stroboscopy of the larynx
History of voice therapy
Trial design
Parallel
Treatments tested in this trial
Stress induction
BehavioralInduction of anticipatory stress to compare voice and speech control and production with and without exposure to stress.
Treatment groups
Trial outcomes
Primary outcomes
Vocal fatigue
Raw scores, Vocal Fatigue Index, VFI Factor 1
BOLD MRI area 4p
MRI activation in regions of interest (BOLD area 4p in mean %) as a function of speech tasks with and without stress induction
Salivary cortisol
Salivary cortisol (nmol/L) to determine stressresponders and nonresponders
Suprahyoid muscle activity
Suprahyoid muscle activity (RMS)
Secondary outcomes
Vocal fatigue
Raw scores, Vocal Fatigue Index, VFI Factor 2 and 3
Voice quality of life
Raw data, Voice Handicap Index, VHI
Vocal tract discomfort
Raw data, Vocal Tract Discomfort Scale, VTD
Informal questionnaire on vocal health
Raw data informal questionnaire on vocal health
Sponsors and contacts
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