Brain and Voice Signatures in Teachers

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age21-39
SponsorUniversity Hospital, Bonn

About this trial

Primary muscle tension dysphonia voice disorder with symptoms of vocal strain and vocal fatigue is common and can have a significant negative impact on quality of Life. Yet, primary muscle tension dysphonia's causes are unknown precluding precise diagnostic classification. Stress and personality are thought to play a role and thus, the project aims to determine the practical and clinical effect of stress on the control of voice and speech in the brain. Participants are female early career teachers and student teachers with symptoms of vocal fatigue, as well as control participants without vocal fatigue, who perform speech tasks on two different occasions. Neural (imaging of brain), psychobiological (saliva, personality), and voice and speech (muscle activity of voice muscles on the neck with surface sensors, audio recordings) data will compare reactivity patterns of teachers who are stressresponders with those who are nonresponders as well as control participants. The central hypothesis is that voice box stress responders have heightened emotion-motor activations involving the emotional voice production pathway, which correlate with changes in voice muscle activity in the anterior neck. The results will provide fundamentally missing data in our understanding of the role of stress in vocal complaints and will yield new insights about the neural underpinnings of primary muscle tension dysphonia. The study findings will have a significant impact on how clinicians identify so-called laryngoresponders to help them prevent voice disorders.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

Lefthandedness

Smoking (past 5 years)

Known changes of the vocal folds (e.g., vocal fold nodules), vocal fold paralysis, surgeries on the larynx or thryoid or current organic or neurological changes of the vocal folds or vocal function per videoendoscopy and -stroboscopy of the larynx

History of voice therapy

Trial design

Design model

Parallel

Treatments tested in this trial

  • Stress induction

    Behavioral

    Induction of anticipatory stress to compare voice and speech control and production with and without exposure to stress.

Treatment groups

100 Participants
are divided into 2 treatment groups
Group A: Teachers/student teachers with vocal fatigueExperimental treatment 1 intervention
Group B: Control groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Vocal fatigue

Raw scores, Vocal Fatigue Index, VFI Factor 1

Time frame
through study completion, an average of 1 month
2

BOLD MRI area 4p

MRI activation in regions of interest (BOLD area 4p in mean %) as a function of speech tasks with and without stress induction

Time frame
through study completion, an average of 1 month
3

Salivary cortisol

Salivary cortisol (nmol/L) to determine stressresponders and nonresponders

Time frame
through study completion, an average of 1 month
4

Suprahyoid muscle activity

Suprahyoid muscle activity (RMS)

Time frame
through study completion, an average of 1 month

Secondary outcomes

1

Vocal fatigue

Raw scores, Vocal Fatigue Index, VFI Factor 2 and 3

Time frame
through study completion, an average of 1 month
2

Voice quality of life

Raw data, Voice Handicap Index, VHI

Time frame
through study completion, an average of 1 month
3

Vocal tract discomfort

Raw data, Vocal Tract Discomfort Scale, VTD

Time frame
through study completion, an average of 1 month
4

Informal questionnaire on vocal health

Raw data informal questionnaire on vocal health

Time frame
through study completion, an average of 1 month

Other outcomes

Sponsors and contacts

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