The purpose of this study is to develop a new tool that uses information collected before life-sustaining treatments are withdrawn to better predict whether a patient will die within the time needed for organ donation to be possible. The tool created should help improve planning for organ donation and provide families and healthcare teams with more accurate information.
Age ≥ 19;
Eligible for DCD
Complete high cervical spinal cord injury (C5 and above)
Pacemaker in situ
Tracheostomy
ICU
Cohort
Prospective
Not listed
To develop a clinically applicable model to predict dying duration in a cohort of patient eligible for donation after circulatory death
Specifically, we aim at assessing the predictive ability of blood-based brain biomarkers, optic nerve sheet diameter as measured by head computed tomography (CT) scans as a surrogate of intracranial pressure and autonomic dysfunction as reflected by abnormal heart rate variability (HRV) to predict the dying duration.
Comparison of the brain-to-heart model to existing models
Our secondary aim will be to compare the created models with available models (e.g., DCD-N, UNOS, Wisconsin) and to physician gestalt
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University of British Columbia
Lead sponsor
Canadian Institutes of Health Research (CIHR)
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
