Brain Diseases on 7.0T Magnetic Resonance Imaging
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorChinese PLA General Hospital
About this trial
This clinical trial studies the use of 7-Tesla (7T)and 3T magnetic resonance imaging (MRI) in detecting brain diseases. 7T MRI has increased detection sensitivity, including more accurate lesion delineation, higher inter-rater agreement. Diagnostic procedures such as 7T MRI may help ultimately improved diagnostic and therapies confidence to inform decision making than standard 3T MRI.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age≥18 and ≤80
Having brain diseases (eg: brain tumor, cerebrovascular diseases)
Having no contraindications against MRI or intravenous contrast agent administration
Clinically stable
Disqualifiers
Age<18 or >80
Pregnancy and other contraindication to MRI scan
Informed consent not obtained
Trial design
Design model
Single group
Treatments tested in this trial
Magnetic resonance imaging
Diagnostic testPatients recruited will receive Magnetic resonance imaging.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
the correspondence between brain tumor cells found in the biopsies and region of interest(ROI) signal intension on the 7T MRI scan and 3T MRI scan
Pathological assessment of biopsy material compared with the lesion's contrast-enhancement signal intension to normal brain white mater on 7T MRI and 3T MRI
Time frame
within a month after biopsy2
The visibility of white matter tracts on 7T MRI
Visualization of white matter tracts will be done with the use of diffusion tensor imaging (DTI) on 7T MRI and measuring the mean diffusivity (MD) value on Post-processing workstation ,and analysis the correlation between these values and pathological.
Time frame
within a month after biopsySecondary outcomes
1
The correlation between the ROI's signal intension on 7T MRI scan and the KPS in 1 month after operation
The correlation analysis between the T1 contrast-enchanced signal intension, Regional cerebral blood flow on 7T MRI (clinical sequence and perfusion) scan and the KPS in 1 month after operation
Time frame
within a month after biopsy2
The visibility of white matter tracts on 7T MRI and 3T MRI
Visualization of white matter tracts will be done with the use of diffusion tensor imaging (DTI) on 7T MRI and 3T MRI. and analysis the difference of the mean diffusivity (MD) value between 7.0T MRI and 3.0T MRI
Time frame
Six months after the biopsySponsors and contacts
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Source ClinicalTrials.gov