Brain Imaging of Cognition Inn Schizophrenia and Depression
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-60
SponsorThe Royal Ottawa Mental Health Centre
About this trial
Schizophrenia and depression are among the most disabling disorders in all of medicine. Cognitive deficits play a key role in patients' disability, affecting their capacity to contribute actively to society by sustaining employment or academic activity. Moreover, cognitive difficulties tend to persist even after the stabilization of other clinical symptoms. Verbal memory and emotion regulation are two important cognitive domains that are impaired in schizophrenia and depression and are associated with patients' functional outcomes. In this study, brain imaging is used to investigate the brain mechanisms underlying these cognitive deficits in these populations.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
age 18-60 years
current Intelligence Quotient (IQ) > 70 as measured by the Wechsler Abbreviated Scale of Intelligence (WASI)
the ability to read and speak fluent English
a diagnosis of schizophrenia, schizoaffective or major depression disorder
Disqualifiers
significant neurological or other medical disorders that may produce cognitive impairment
a recent history of substance abuse or dependence (within the past 3 months)
any magnetic resonance imaging (MRI) contraindications (e.g. metallic head implant, history of seizure, pacemaker)
decisional incapacity requiring a guardian
Trial population
Individuals with an official diagnosis of: Schizophrenia, Schzioaffective or Major Depressive Disorders.
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
90 Participants
are grouped into 3 trial groupsGroup A: Individuals with Schizophrenia or Schzioaffective Disorders
Group B: Individuals with Major Depressive Disorder
Group C: Healthy Individuals
Trial outcomes
Primary outcomes
1
Measuring brain activity using resting-state and task-based functional MRI
To better understand the mechanisms underlying cognitive problems in our populations of interest
Time frame
Final Visit (Visit 3)Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov