The goal of this prospective, exploratory and observational study is to learn about in healthy volunteers and patients with prolonged disorders of consciousness(pDoC). The main questions it aims to answer are:
1. Observe the similarities and differences of polysomnography between pDoC patients and healthy volunteers, and analyze the characteristic brain network changes based on polysomnography 2. To observe the similarities and differences of polysomnography in pDoC patients before and after Insertion of spinal cord electric stimulator under general anesthesia,and analyze the changes of anesthesia characteristic brain network in patients with consciousness disorders based on polysomnography. 3. To observe the similarities and differences of polysomnography in pDoC patients before and after spinal cord stimulation,and analyze the characteristic changes of brain network after spinal cord stimulation.
We will record the 8h polysomnography of healthy volunteers,record the polysomnography of DOC patients before and 24 hours after operation;and record the 24h polysomnography of patients with spinal cord electric stimulator.
Aged 18-65, native Chinese
No history of sleep apnea
No history of insomnia
Volunteer to participate in this study and obtain informed consent.
Healthy volunteers took hypnotic drugs 72 hours before the study
Continuous sedation treatment was carried out within 72 hours before the study
The integrity of brain structures such as open head injury and brain parenchyma resection
Intracranial compliance decreased due to hydrocephalus
The people with prolonged disorders of consciousness who will be implanted with spinal cord electric stimulator under general anesthesia.
Cohort
Prospective
General Anesthetics
DrugGeneral anesthetics used in spinal cord electrical stimulator insertion surgery
Characteristics of sleep in pDoC patients
Characteristics of sleep in pDoC patients compared with healthy volunteers
Sleep EEG and characteristic brain network in pDoC patients before and after anesthesia
Sleep electroencephalogram and characteristic brain network of pDoC patients before and after starting the spinal cord electric stimulator
Consciousness recovery of patients with pDoC 30 days, 90 days and 180 days after operation
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