Health TrialsbyHealthPanel

Breaking Sitting with High-intensity Interval Training for Brain Health

ConditionAging
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-75
SponsorUniversity of Illinois at Urbana-Champaign

About this trial

This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in cognitively normal older adults. This trial will test the feasibility of HIIT breaks to sitting. It will also address several important but unanswered questions: (1) Does interrupting sitting with short HIIT breaks improve frontoparietal function? (2) Can interrupting sitting with HIIT breaks improve cognitive functions?

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age 40-75 years

BMI <40 kg/m2

Sedentary (≥ 6 h/day sitting by a survey question)

Physically inactive adults based on the CSEP-PATH: Physical Activity and Sedentayr Behaviour Questionnaire (PASB-Q) Adult (low or medium physical activity range equivalent to less than 300 min of moderate intensity physical activity per week)

Disqualifiers

Physical disability or musculoskeletal disease prohibitive to vigorous exercise

Learning disabilities

Cognitive impairment (MoCA <26)

Type 1 or 2 diabetes

Trial design

Design model

Crossover

Treatments tested in this trial

  • High-Intensity Interval Training (HIIT) Breaks to Sitting

    Behavioral

    HIIT Breaks: a 3.5-hour sitting will be interrupted every 30 min with 6-min HIIT Breaks. During sitting participants will engage in standardized sedentary activities. Each 6-min HIIT break comprises a one-minute warm-up, followed by a 2-minute high-intensity interval, one minute rest (sitting on a cycle ergometer) followed by another 2 minutes at high intensity.

  • Light-Intensity Interval Training (LIIT) Breaks to Sitting

    Behavioral

    LIIT Breaks: a 3.5-hour sitting will be interrupted every 30 min with 6-min LIIT Breaks. Each 6-min LIIT break comprises a one-minute warm-up, followed by a 2-minute light-intensity interval, one minute rest (sitting on a cycle ergometer) followed by another 2-minute light-intensity interval.

Treatment groups

54 Participants
are divided into 2 treatment groups
Group A: High-Intensity Interval Training (HIIT) BreaksActive comparator 1 intervention
Group B: Light-Intensity Interval Training (HIIT) BreaksSham comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in task-evoked brain activity

EEG will be used to measure event-related brain potentials including the P3b-component during an inhibitory control task.

Time frame
Immediately before intervention, 2 x during the intervention (50 min and 120 min into the intervention), and immediately after the intervention

Secondary outcomes

1

Change in cognitive functions

A modified Eriksen flanker task will be used to measure inhibitory control.

Time frame
Immediately before intervention, 2 x during the intervention (50 min and 120 min into the intervention), and immediately after the intervention
2

Change in cognitive functions

An antisaccade tasks will be used to measure inhibitory control. A mnemonic discrimination task will be used to measure episodic memory.

Time frame
Immediately before intervention and immediately after the intervention
3

Change in resting stated and task evoked brain activity

EEG will be used to measure functional connectivity at rest and during engagement in inhibitory control and episodic memory tasks.

Time frame
Immediately before intervention and immediately after the intervention

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Illinois at Urbana-Champaign

Lead sponsor

Northeastern University

Collaborator

National Institute on Aging (NIA)

Collaborator

Source ClinicalTrials.gov
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