Some people hear voices or sounds that other people cannot hear; these are called auditory hallucinations. The study aims to understand what is happening in the brain when this occurs and will use brain scans to learn more. Greater understanding should help develop better treatments in the future.
Age 16-65 years.
A score of at least 3 on the state section of the Auditory Perceptual Trait and State scale (APTS).
If using an antipsychotic drug, participants must be on a stable dose of any medication during the baseline measures.
Sufficient understanding of the nature of the study and any hazards of participating in it, or suitable consultee who can understand this and provide an opinion of what the participant's wishes would be if the participant does not have capacity, if appropriate to do so.
Clinically relevant abnormal history, or laboratory values at the pre-study screening assessment or participation in other research studies that could interfere with the objectives of the study or the safety of the participant, as deemed significant for a study researcher.
Impaired endocrine, cardiac, pulmonary, thyroid, haematological, hepatic, respiratory, neurological, immunological or renal function, or other major disease (e.g. cancer) deemed clinically significant at the time of the study.
Recent history (i.e. in the last 12 months) of epilepsy or seizures.
Homicidal ideation or intent, as judged by a researcher; suicidal ideation, with some intent to act, or suicidal behaviour, as judged by a researcher.
PWLEP: people with auditory perceptual alterations able to get to the study site in London. Controls: people without psychosis or auditory perceptual alterations able to get to the study site in London.
Case-control
Cross-sectional
Not listed
E/I balance determined using the computational model based on the 40-Hz auditory steady-state response (ASSR) EEG response.
Computational model will be created after study end, using EEG data acquired at the baseline study visit.
Mismatch Negativity (MMN): E/I balance determined using MMN amplitude and latency measured using EEG.
Relationship between E/I balance and auditory perceptual symptom severity, assessed using the Auditory Perceptual Trait and State Scale.
EEG Resting-State Activity: Power across frequency bands (delta, theta, alpha, beta, gamma) during resting-state EEG.
Auditory Oddball P300: Amplitude of the P300 event-related potential in response to an auditory oddball, measured using EEG.
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King's College London
Lead sponsor
University of Manchester
Collaborator
University College, London
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
