Can Exercise Electrocardiography Discriminate Hypertensive Heart Disease From Obstructive Coronary Artery Disease? A Multimodality Imaging Study

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-99
SponsorUniversity of Pisa

About this trial

To evaluate the ability of exercise ECG to discriminate between hypertensive heart disease-related and CAD-related abnormalities

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients with CAD and LVH

Disqualifiers

Patients with RBBB

Trial population

consecutive patients undergoing evaluation for suspected coronary artery disease will undergo exercise ECG testing (ExECG), transthoracic echocardiography (TTE), stress cardiac magnetic resonance (CMR), and coronary computed tomography angiography (CCTA). Patients will be stratified into four groups according to the presence or absence of LVH and obstructive CAD: LVH with obstructive CAD LVH without obstructive CAD No LVH with obstructive CAD No LVH without obstructive CAD

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

30 Participants
are grouped into 4 trial groups
Group A: LVH with obstructive CAD
Group B: LVH without obstructive CAD
Group C: No LVH with obstructive CAD
Group D: No LVH without obstructive CAD

Trial outcomes

Primary outcomes

1

diagnostic performance of exercise ECG across the four predefined groups.

Differences in ECG response patterns will be compared according to the presence of LVH and obstructive CAD. Multivariable analysis will be performed to identify independent ECG predictors associated with obstructive CAD and inducible ischemia.

Time frame
From enrollment through completion of all diagnostic evaluations, assessed up to 3 months after enrollment.

Secondary outcomes

Other outcomes

Sponsors and contacts

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