Can Exercise Rewire the Brain Addiction Circuitry?
ConditionPhysical Exercise
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-24
SponsorUniversity of Minho
About this trial
The aim of the present study is to apply neuroimaging techniques to investigate how physical exercise may influence the addiction circuitry, ultimately reducing alcohol consumption and craving in youth binge drinkers. This proposal will advance knowledge on how exercise may modulate the neurocircuitry of addiction. Uncovering the neurobiological mechanisms underlying the interactive neural effects of exercise and alcohol intake may provide additional scientific insights for the development of preventive and intervention programs for youth BD and AUD.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
binge drinking > or = 5 ; > or =4 for women alcoholic drinks
in the same time window (±2h)
at least once per month
<150 minutes of physical activity per week
Disqualifiers
Major and/or unstable medical conditions
Physical limitations that may constraint the practice of exercise
Cardiovascular and respiratory insufficiency
History of traumatic brain injury or neurological disorder
Trial design
Design model
Parallel
Treatments tested in this trial
Aerobic Exercise
BehavioralParticipants allocated to the Aerobic condition will be following a 4 month-intervention aerobic exercise protocol of 3 weekly interleaved sessions with a 50 minutes duration
Agility-Cognitive Exercise
BehavioralParticipants allocated to the Agility-Cognitive condition will be following a 4 month-intervention agility-cognitive exercise protocol of 3 weekly interleaved sessions with a 50 minutes duration
Stretching/relaxation
BehavioralParticipants allocated to the stretching control condition will be following a 4 month-intervention protocol of 1 weekly session with a 50 minutes duration
Treatment groups
60 Participants
are divided into 3 treatment groupsGroup A: Experimental condition 1Experimental treatment 1 intervention
Group B: Experimental condition 2Experimental treatment 1 intervention
Group C: Control conditionActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Behavioral: alcohol consumption
Number of drinks per binge drinking episode
Time frame
Through study completion, an average of 1 year2
Behavioral: binge episodes
Number of binge drinking episodes
Time frame
Through study completion, an average of 1 year3
Behavioral : drunkenness
Percentage of drunkenness
Time frame
Through study completion, an average of 1 year4
Psychological (craving levels)
Scores in the Alcohol Craving Questionnaire (The cutoff points for total scale points are: 12-17 = minimal desire, 18-25 = mild, 26-42 = moderate and 43 or more = severe)
Time frame
Through study completion, an average of 1 yearSecondary outcomes
1
Monetary Incentive Delay Task (included in the fMRI paradigm) - hits
Accuracy, measured through the number of hits to assess the hypothetical differences in participant's level of achievement between the pretest, posttest and follow-up assessments.
Time frame
Through study completion, an average of 1 year2
Monetary Incentive Delay Task (included in the fMRI paradigm) - reaction time
Reaction times, measured as seconds needed to give a response to assess the hypothetical differences in participant's level of achievement between the pretest, posttest and follow-up assessments.
Time frame
Through study completion, an average of 1 year3
Maximal oxygen consumption (VO2max)
VO2max (ml/kg/min) will be measured in the pretest and posttest evaluations to assess the effects of the physical exercise protocol on cardiovascular fitness.
Time frame
Through study completion, an average of 1 year4
Brain-derived neurotrophic factor (BDNF)
BDNF (pg/ml) concentrations measured in saliva will be measured in pre-intervention, post-intervention, at the midpoint of the intervention (2 months), and at the follow-up to assess the effects of the physical exercise protocol on neuroplasticity-related molecular markers.
Time frame
Through study completion, an average of 1 yearLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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