Health TrialsbyHealthPanel

Can Food Timing Reduce Your Diabetes Risk?

ConditionDietary Habits
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorBrigham and Women's Hospital

About this trial

The goal of this clinical trial is to test whether food timing impacts metabolic health in healthy participants.

Participants will:

* complete 2 inpatient stays * be provided with test meals * have frequent blood draws

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy with no acute or chronic medical and psychiatric disorders

BMI: 18.5-29.9 kg/m2

Disqualifiers

Smokers, current tobacco or e-cigarette use

Drug or alcohol dependency

Pregnant

Trial design

Design model

Crossover

Treatments tested in this trial

  • Day shift protocol - Diet order A-B

    Behavioral

    Research participants will be assigned to day shift condition and Diet A-B order condition.

  • Day shift protocol - Diet order B-A

    Behavioral

    Research participants will be assigned to day shift condition and Diet B-A order condition.

  • Night shift protocol - Diet order A-B

    Behavioral

    Research participants will be assigned to simulated night shift condition and Diet A-B order condition.

  • Night shift protocol - Diet order B-A

    Behavioral

    Research participants will be assigned to simulated night shift condition and Diet B-A order condition.

Treatment groups

48 Participants
are divided into 4 treatment groups
Group A: Day shift protocol with diet AExperimental treatment 2 interventions
Group B: Day shift protocol with diet BExperimental treatment 2 interventions
Group C: Night shift protocol with diet AExperimental treatment 2 interventions
Group D: Night shift protocol with diet BExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Difference in glucose tolerance between Meal Conditions and Shift Work

Glucose incremental area under the curve (AUC) from mixed meal tests

Time frame
24 hours
2

Difference in diet-induced thermogenesis between Meal Conditions and Shift Work

Postprandial energy expenditure incremental area under the curve (AUC) from mixed meal tests

Time frame
24 hours
3

Difference in plasma triglyceride level between Meal Conditions and Shift Work

Triglyceride area under the curve (AUC) over 24 hours

Time frame
24 hours

Secondary outcomes

1

Difference in insulin sensitivity between Meal Conditions and Shift Work

Insulin sensitivity index derived from Oral Minimal Model

Time frame
24 hours
2

Difference in beta-cell function between Meal Conditions and Shift Work

Beta-cell function index derived from Oral Minimal Model

Time frame
24 hours
3

Difference in 24-h glycemia between Meal Conditions and Shift Work

Glucose area under the curve (AUC) based on CGM over 24 hours

Time frame
24 hours
4

Difference in postprandial incretin level between Meal Conditions and Shift Work

Incretin incremental area under the curve (AUC) from mixed meal tests

Time frame
24 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Brigham and Women's Hospital

Lead sponsor

Source ClinicalTrials.gov
Apply now