Health TrialsbyHealthPanel

Canadian SCAD Study

ConditionsSpontaneous Coronary Artery DissectionSCADFibromuscular Dysplasia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCardiology Research UBC

About this trial

Natural history multicenter, prospective, observational registry with 10-year follow-up

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients admitted with ACS (STEMI, NSTEMI or unstable angina)

Documented SCAD on a coronary angiogram (including diagnosis with OCT or IVUS)

Disqualifiers

None

Trial population

Patients admitted with ACS (STEMI, NSTEMI or unstable angina) and diagnosed with SCAD during direct coronary angiography. The study imaging corelab will review all films before participant enrollment.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Genetic sub-study

    Genetic

    One time saliva sample collection

Treatment groups

3,000 Participants
are divided into 1 treatment group
Group A: Study group1 intervention

Trial outcomes

Primary outcomes

1

In-hospital CV outcomes

Composite (Death, MI, CVA, Unplanned revascularization, Heart failure)

Time frame
From date of hospital admission to discharge up to 8 weeks
2

Long-term CV outcomes

Composite (Death, MI, CVA, Revascularization, Heart failure)

Time frame
at 10 Years post index event

Secondary outcomes

1

Arterial healing post SCAD

Angiographic healing

Time frame
at 6 weeks post discharge post index event
2

Coronary revascularization success

Composite (TIMI 3 flow, \<50% stenosis, and no residual dissection)

Time frame
During index hospitalization

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cardiology Research UBC

Lead sponsor

John GB Mancini, MD

Collaborator

Karin Humphries, DSc

Collaborator

Source ClinicalTrials.gov
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