CAPRI National Juvenile Idiopathic Arthritis Registry
ConditionJuvenile Idiopathic Arthritis (JIA)
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeUp to 18
SponsorUniversity of British Columbia
About this trial
Juvenile Idiopathic Arthritis (JIA) is a disorder of unknown cause characterized by chronic inflammation of the joints and other organs. It affects about 1 in a 1000 Canadian children and if untreated it can produce lifelong disability. The Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) includes most pediatric rheumatologists in Canada. They have successfully collaborated for the past 20 years producing groundbreaking research on the modern course and outcomes of JIA. The CAPRI JIA Registry is an ongoing universal registry of Canadian children with JIA that collects longitudinal data on disease course, outcomes and adverse events to inform healthcare decisions and to gain new insights into the disease and its treatment.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
All patients newly diagnosed with JIA within the last 3 months
All patients who participated in the original ReACCh-Out study
LEAP study patients from 'newly diagnosed' and 'ReACCh-Out' cohorts who have completed their two year follow up in LEAP
Disqualifiers
Patients with an unconfirmed JIA diagnosis
Patients diagnosed with JIA more than 3 months prior to the clinic visit, who were not followed in LEAP and /or ReACCh-Out studies.
If the family as a whole is unable to answer questionnaires in English or French
Trial population
Pediatric rheumatology clinic patients at study sites
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Proportion of Children with Clinical inactive disease
This is an accepted validated composite measure requiring all of the following: No active joints, no extra-articular manifestations, a physician global assessment of disease activity of less than 1, morning stiffness of 15 min or less, and normal inflammatory markers (ESR or CRP).
Time frame
At one yearSecondary outcomes
1
Juvenile Arthritis Disease Activity Score
This is an accepted validated measure composed of the sum of physician global assessment, parent global assessment and up to 10 active joints.
Time frame
One year2
Pain intensity
Severity of arthritis pain in the last week, from 0 to 10
Time frame
One year3
Juvenile Arthritis Quality of Life Questionnaire
Composite measure of quality of life with total of 72 items, score from 1 (best) to 7 (worst) quality of life.
Time frame
One year4
Childhood Health Assessment Questionnaire Disability Index
Composite measure of functional disability, score from 0 (no disability) to 3 (severe disability)
Time frame
One yearSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of British Columbia
Lead sponsor
Children's Hospital of Eastern Ontario
Collaborator
The Hospital for Sick Children
Collaborator
IWK Health Centre
Collaborator
London Health Sciences Centre
Collaborator
Royal University Hospital Foundation
Collaborator
University of Manitoba
Collaborator
University of Calgary
Collaborator
Alberta Children's Hospital
Collaborator
Memorial University of Newfoundland
Collaborator
McMaster University
Collaborator
McMaster Children's Hospital
Collaborator
McGill University Health Centre/Research Institute of the McGill University Health Centre
Collaborator
Université de Montréal
Collaborator
Laval University
Collaborator
Source ClinicalTrials.gov