Capturing Autobiographical Memory Formation in Real World Spaces Using Multimodal Recordings

ConditionsEpilepsy Autobiographical Memory

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorUniversity of Utah

About this trial

The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted neurostimulation devices (e.g., NeuroPace RNS) for epilepsy treatment. The main questions it aims to answer are:

How does the brain encode and retrieve real-world autobiographical memories? Can multimodal data integration enhance our understanding of memory-related cognitive and neural mechanisms?

Participants will:

* Use a smartphone-based recording application (CAPTURE app) to collect real-world data. * Have their wearable sensor data (e.g., audio-visual, accelerometry, GPS, autonomic physiology, eye tracking) synchronized with invasive neural recordings.

Researchers will analyze these multimodal data streams to develop new analytic approaches for studying memory formation in naturalistic settings, with the long-term goal of informing neuromodulation-based memory enhancement treatments for individuals with memory disorders.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

18 years of age or older

healthy to minor cognitive impairment

Disqualifiers

younger than 18 years of age

more than minor cognitive impairment

Trial design

Design model

Single group

Treatments tested in this trial

Free and Cued Recall Memory. Temporal Sequence and Spatial Memory
Behavioral
Memory for real-world episodic experiences will be tested in the laboratory first with free recall (spoken narration of their recollections from each environment) and then with cued recall, in which participants will be cued with an event image from the CAPTURE app, a map location, or a relative time and asked to recall the other two non-cued pieces of episodic information (event, place, or time). Because we will know the 'ground truth', the cued recall test will allow us to measure how accurately the participant is able to remember key details of each episode. We will also assess temporal order memory by asking participants to arrange 1st person images in the order in which they occurred, and we will assess spatial memory by asking them to place each image on a schematic map of the venue.

Treatment groups

50 Participants

are divided into 2 treatment groups

Group A: Neuroethical Assessment GroupNo intervention 0 interventions

Group B: Multi-Modal Recording System Assessment GroupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Intracranial EEG power in Theta Band

iEEG power in the theta band between 4-8 Hz, will be assessed to identify the real-world experience features that contribute to changes in this important neural power band for memory encoding.

Time frame

4 days

Intracranial EEG power in Gamma Band

iEEG power in the gamma band between 30-100 Hz, will be assessed to identify the real-world experience features that contribute to changes in this important neural power band for memory encoding.

Time frame

4 days

Intracranial EEG normalized aperiodic exponent

This feature of intracranial EEG will be assessed as a broadband state-level change in brain activity during the participant's real-world experiences.

Time frame

4 days

Secondary outcomes

Eye fixation duration to remembered experiences

Using eye-tracking, we will use the duration in time participants fixate on remembered experiences as a measure of visual attention.

Time frame

4 days

Other outcomes

Questionnaire on Attitudes Regarding Neuroethics

This is a survey for people with responsive neurostimulation (RNS) devices. We ask some general demographic information. Then we will ask questions about how patients feel about the sharing of various types of personal data and how much they care about privacy.

Time frame

Day 1

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Utah

Lead sponsor

National Institutes of Health (NIH)

Collaborator

National Institute of Mental Health (NIMH)

Collaborator

University of California, San Diego

Collaborator

University of California, Los Angeles

Collaborator

Source ClinicalTrials.gov

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