Cardiac Biomarkers for the Quantification of Myocardial Damage After Cardiac Surgery
ConditionCardiac Valve Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorJena University Hospital
About this trial
The aim of the study is to clarify whether the perioperative release of the cardiac biomarkers troponin I, troponin T and CK-MB consistently correlate with visualizable myocardial damage, and to what extent these biomarkers are comparable by means of their kinetics and dynamics.
Due to the uncertainty regarding the validity of cardiac biomarkers in the diagnosis of myocardial infarction, the answer to these questions could have a considerable influence on internationally valid guidelines and definitions. International studies, especially in the field of coronary surgery and coronary artery disease treatment refer to these definitions, in particular, the adequate treatment of affected patients is directly dependent on them.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Indication for isolated aortic or mitral valve surgery
Written informed consent
Age ≥ 18 years
Disqualifiers
Presence of coronary artery disease (excluded within the last 6 months)
Allergy to gadolinium
Cochlear implant
Deep brain stimulation
Trial population
Patients with indication for isolated aortic or mitral valve surgery and exclusion of coronary artery disease.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Correlation biomarker release and LGE-cMRI
Correlation of the peak value of the respective biomarker with the amount of perioperatively induced myocardial damage quantified by LGE-cMRI.
Time frame
pre-surgery and 5 days post-surgerySponsors and contacts
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Source ClinicalTrials.gov