Cardiac Transplant Metabolomics With and Without Rejection
ConditionHeart Transplant Rejection
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorWestern University, Canada
About this trial
Patient who received a heart transplant may develop organ rejection. Currently, an invasive biopsy of the heart needs to be performed to diagnose rejection. The purpose of this research study is to identify novel metabolic biomarkers that can be developed into a blood test that can identify signs of rejection without doing a heart biopsy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
All patients with heart transplant undergoing routine endomyocardial biopsy and blood work for transplant rejection screening and workup.
Patients or substitute decision makers are able to provide informed consent to agree to participate in this study.
Disqualifiers
Patients or substitute decision makers declined to participate in this study.
Trial population
Patients who had cardiac transplant undergoing routine blood work and endomyocardial biopsy in the catheterization lab at London Health Sciences Centre - University Hospital.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Extra blood samples (5-10 mL) drawn
Diagnostic testExtra blood samples will be sent for metabolomics analysis.
Treatment groups
100 Participants
are divided into 2 treatment groupsGroup A: No pathological signs of rejection1 intervention
Group B: With pathological signs of rejection1 intervention
Trial outcomes
Primary outcomes
1
Metabolomics differences detected in the blood sample of patient with signs of transplant rejection vs. no rejection.
25 blood samples in the no rejection group and 25 blood samples in the rejection group will be collected.
Time frame
1-2 year to obtain these samples.Locations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Western University, Canada
Lead sponsor
Canadian Cardiovascular Society
Collaborator
Bayer
Collaborator
University of Alberta
Collaborator
Queen's University
Collaborator
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: