This study's primary purpose is to determine the potential relationship between cardiometabolic disease, specifically insulin resistance (HOMA-IR), and maternal lipid oxidation.
Age 18-45
Any pre-pregnancy BMI
At least one high risk OR one moderate risk factor for pre-eclampsia based on ACOG and USPSTF guidelines
Willingness to adhere to aspirin therapy
Type 2 Diabetes Mellitus
Type 1 Diabetes Mellitus
Current gestational diabetes mellitus
Current/active platelet disorder or bleeding diathesis (thrombocytopenia of any etiology, idiopathic thrombocytopenic purpura/ITP, thrombotic thrombocytopenic purpura/TTP, von Willebrand disease, etc.)
Pregnant individuals at risk for preeclampsia
Cohort
Prospective
Not listed
Early Pregnancy Fasting Insulin (mIU/mL)
Early pregnancy fasting insulin level (mIU/mL) in venous blood
Early Pregnancy Homeostatic Model Assessment for Insulin Resistance
Approximates early pregnancy insulin resistance.
Early Pregnancy Fasting Lipid Oxidation Rate (g/min)
Early pregnancy fasting lipid oxidation rate measures whole body lipid oxidation, which is assessed using indirect calorimetry
Late Pregnancy Fasting Insulin (mIU/mL)
Late pregnancy fasting insulin level (mIU/mL) in venous blood
Early Pregnancy Fasting Resting Metabolic Rate (kcal/day)
Early pregnancy resting metabolic rate describes whole body caloric expenditure, which is assessed using indirect calorimetry
Early Pregnancy Fasting Resting Respiratory Quotient
Early pregnancy resting respiratory quotient describes whole body caloric expenditure, which is assessed using indirect calorimetry
Early Pregnancy Fasting Carbohydrate Oxidation Rate (g/min)
Early pregnancy fasting carbohydrate oxidation rate measures whole body carbohydrate oxidation, which is assessed using indirect calorimetry
Early Pregnancy Fasting Glucose (mg/dL)
Early pregnancy fasting glucose level (mg/dL) in venous blood
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