About this trial
Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth restriction (baby being small) have twice the risk of developing heart disease and diabetes later in life, compared to women who have a healthy pregnancy.
This study aims to assess risk factors for heart disease and diabetes in women who are actively trying to conceive, before and during their pregnancy, and 9-12 months after delivery of their baby, to see whether placental syndromes make a difference to their heart health. This will allow us to understand, if, and how, placental syndromes increase the risk of heart disease and diabetes, and, therefore, how best to reduce this risk and potentially prevent placental syndromes in the future. The investigators will also recruit women who are NOT planning pregnancy, as a control group.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Nulliparous (no previous pregnancy beyond 20 weeks' gestation)
Actively considering pregnancy within approximately 12 months
Aged between 18 and 45 years
Ability to consent and willing to participate
Disqualifiers
Currently pregnant
Established infertility
Planning or actively using fertility treatments (e.g. IVF, ICSI, FET, IUI)
Assigned male sex at birth
Trial population
Nulliparous women to maximise the occurrence of placental syndrome.
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
QRISK3
Predicted lifetime CVD risk
Secondary outcomes
Blood Pressure Systolic, Blood Pressure Diastolic Pulse Wave Analysis: Supine Systolic BP, Supine diastolic BP, Central Systolic BP, Central diastolic BP, Supine MAP
BP (mmHg)
Height
m
BMI
kg/m2
BMR
KJ
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Cambridge University Hospitals NHS Foundation Trust
Lead sponsor
University of Cambridge
Collaborator
University of Bristol
Collaborator
University College, London
Collaborator
King's College London
Collaborator
Imperial College London
Collaborator
St George's, University of London
Collaborator
University of Glasgow
Collaborator
Wellcome Trust
Collaborator