Cardiopulmonary Exercise Testing in Cardiosurgery Patients

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorSt. Anne's University Hospital Brno, Czech Republic

About this trial

Cardiopulmonary exercise testing (CPET) is considered to be a gold standard in pre-operative risk assessment and stratification of high risk patients scheduled for major surgery. Surprisingly, only a limited number of studies examined the prognostic role of CPET in cardiothoracic surgery. This is in contrast with rather poor discriminating quality of cardiovascular surgery risk scores and predominantly elderly cardiovascular surgery patients, with significant comorbidity and high degree of frailty. Recently, CPET was shown feasible in coronary artery bypass grafting surgery candidates. Additionally, the rest parameter, which is the partial pressure of end-tidal carbon dioxide (PETCO2) and a submaximal exercise parameter (the VE/VCO2 slope) with good prognostic utility across multiple respiratory exchange ratio values), has been shown to predict mortality and post-operative complications.

Whether these rest and submaximal exercise parameters can be used to predict postoperative complications in cardiovascular surgery patients is yet to be determined.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

patients scheduled for coronary artery bypass graft surgery

Disqualifiers

not able to perform cardiopulmonary exercise testing, off-pump revascularization, without full sternotomy, previous cardiac surgery

Trial population

Patients scheduled for coronary artery bypass graft surgery

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Cardiopulmonary exercise testing

    Diagnostic test

    Subjects will undergo pre-operative cardiopulmonary exercise testing.

Treatment groups

130 Participants
are divided into 1 treatment group
Group A: coronary artery bypass graft candidates1 intervention

Trial outcomes

Primary outcomes

1

post-operative pulmonary complications

pneumonia, atelectasis, respiratory failure, ARDS

Time frame
within 30 post-operative days
2

post-operative cardiovascular complications

new arrhythmias (atrial fibrillation, supraventricular tachycardia, etc.), myocardial infarction/minimal myocardial lesion, hypotension, heart failure, pulmonary edema, pulmonary embolism, cardiopulmonary resuscitation

Time frame
within 30 post-operative days

Secondary outcomes

1

Hospital and Intensive care length of stay

Hospital and Intensive care length of stay

Time frame
within 30 post-operative days

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

St. Anne's University Hospital Brno, Czech Republic

Lead sponsor

Centre of Cardiovascular and Transplantation Surgery, Czech Republic

Collaborator