About this trial
Cardiopulmonary exercise testing (CPET) is considered to be a gold standard in pre-operative risk assessment and stratification of high risk patients scheduled for major surgery. Surprisingly, only a limited number of studies examined the prognostic role of CPET in cardiothoracic surgery. This is in contrast with rather poor discriminating quality of cardiovascular surgery risk scores and predominantly elderly cardiovascular surgery patients, with significant comorbidity and high degree of frailty. Recently, CPET was shown feasible in coronary artery bypass grafting surgery candidates. Additionally, the rest parameter, which is the partial pressure of end-tidal carbon dioxide (PETCO2) and a submaximal exercise parameter (the VE/VCO2 slope) with good prognostic utility across multiple respiratory exchange ratio values), has been shown to predict mortality and post-operative complications.
Whether these rest and submaximal exercise parameters can be used to predict postoperative complications in cardiovascular surgery patients is yet to be determined.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
patients scheduled for coronary artery bypass graft surgery
Disqualifiers
not able to perform cardiopulmonary exercise testing, off-pump revascularization, without full sternotomy, previous cardiac surgery
Trial population
Patients scheduled for coronary artery bypass graft surgery
Trial design
Cohort
Prospective
Treatments tested in this trial
Cardiopulmonary exercise testing
Diagnostic testSubjects will undergo pre-operative cardiopulmonary exercise testing.
Treatment groups
Trial outcomes
Primary outcomes
post-operative pulmonary complications
pneumonia, atelectasis, respiratory failure, ARDS
post-operative cardiovascular complications
new arrhythmias (atrial fibrillation, supraventricular tachycardia, etc.), myocardial infarction/minimal myocardial lesion, hypotension, heart failure, pulmonary edema, pulmonary embolism, cardiopulmonary resuscitation
Secondary outcomes
Hospital and Intensive care length of stay
Hospital and Intensive care length of stay
Sponsors and contacts
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St. Anne's University Hospital Brno, Czech Republic
Lead sponsor
Centre of Cardiovascular and Transplantation Surgery, Czech Republic
Collaborator