The purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease later in life.
Participant is willing and able to give informed consent for participation in the study
Male or female, aged 30 to 40 years at time of enrolment
Participant previously took part in the ALSPAC study
Able (in the investigator's opinion) and willing to comply with all study requirements
Pregnant or lactating when they are due to attend for study visit 1
Less than six months postpartum
Planning to donate blood within two weeks prior to study visit 1
Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study
Of the 200 young adults followed up from the ALSPAC study, 100 will have been born to a hypertensive pregnancy and 100 following an uncomplicated pregnancy. At time of follow-up, they will be 30 to 40 years of age. At the 25-year follow-up in Bristol, there were 610 individuals born to hypertensive pregnancies.
Cohort
Other
History of being born to hypertensive or normal pregnancy
Other interventionCLARITY is an observational study whereby participants will attend one 4-hr visit the Division of Cardiovascular Medicine, University of Oxford at the John Radcliffe Hospital in Oxford, with the option to split the study visit over two days for convenience. Participants will be invited by the ALSPAC study team to attend a study visit in Oxford where the investigators will use MRI and other imaging modalities to study the brain, heart, liver, kidneys, and vasculature using standardised protocols. A dataset including information from previous follow-up of these cohorts and the detailed pregnancy data available within ALSPAC will be generated by the study team in Bristol and integrated with available data from the Oxford cohorts.
Cardiac right ventricular mass
Magnetic resonance imaging (MRI) assessment of cardiac right ventricular mass indexed to body surface area (in g and g/m\^2)
Cardiac left ventricular mass
MRI assessment of cardiac left ventricular mass indexed to body surface area (in g and g/m\^2)
Cardiac right ventricular end-diastolic volume
MRI assessment of cardiac right ventricular end-diastolic volume indexed to body surface area (in ml and ml/m\^2)
Cardiac right ventricular stroke volume
MRI assessment of cardiac right ventricular stroke volume indexed to body surface area (in ml and ml/m\^2)
Cardiac left ventricular end-diastolic volume
MRI assessment of cardiac left ventricular end-diastolic volume indexed to body surface area (in ml and ml/m\^2)
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University of Oxford
Lead sponsor
University of Bristol
Collaborator
