Case Control Study to Identify Modifiable Risk Factors for Colorectal and Breast Cancer in Nigeria

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorObafemi Awolowo University Teaching Hospital

About this trial

This project is a case-control study which seeks to identify modifiable risk factors for breast and colorectal cancer in Nigeria. Both cases and controls will be required to complete a risk factor questionnaire which contains information about their diet, physical activity, past medical history and life style factors. They will also be required to provide information on their body composition through the use of a bioimpedance machine which measures the body mass index, fat and total body water percentage.

Based on the existing ARGO platform where a current colorectal cancer study is going on, approximately 400 patients with a prior diagnosis or a new diagnosis will be recruited into this study. Comparatively, we will select our 400 controls from two groups of participants who are free of cancer and gastrointestinal diseases.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial population

Based on the existing African Research Group for Oncology platform where a current colorectal study is going on, 400 patients with a prior diagnosis and a new diagnosis of colorectal cancer or breast cancer will be recruited into this study. A combined total of 400 controls will be recruited from community mobilization groups and the Outpatient Health Center at OAU who are free of cancer and gastrointestinal diseases.

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • Questionnaire

    Behavioral

    Questionnaire containing questions regarding diet, physical activity, past medical history and life style practices.

  • Bioimpedance/Body Composition Unit

    Device

    Patients will provide information on body composition through the use of a bioimpedance machine which measures the body mass index, fat and total body water.

Treatment groups

800 Participants
are divided into 2 treatment groups
Group A: Colorectal Cancer (Cases)2 interventions
Group B: Controls2 interventions

Trial outcomes

Primary outcomes

1

Development and Validation of Questionnaire For Assessing Modifiable Risk Factors for Cancer in Sub-Saharan Africa

Time frame
2 years
2

Determination of Novel Modifiable Cancer Risk Factors in a Nigerian Population

We will determine the presence of established, plausible, and novel cancer risk factors in cases (n=400) and controls (n=400) in Nigeria

Time frame
2 years

Secondary outcomes

Other outcomes

Sponsors and contacts

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Obafemi Awolowo University Teaching Hospital

Lead sponsor

Memorial Sloan Kettering Cancer Center

Collaborator

Lagos State University

Collaborator

University of Ilorin Teaching Hospital

Collaborator

Federal Medical Centre, Owo

Collaborator

University of Maiduguri Teaching Hospital

Collaborator

National Hospital, Abuja

Collaborator