CCTA Improves Clinical Management of Stable Chest Pain

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorTianjin Chest Hospital

About this trial

The investigator aims to prospectively enroll patients who were referred for coronary computed tomography angiography (CCTA) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD). All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary. This study will determine if CCTA-based imaging evaluation can provide more informaton to improve clinical management for SCP, including fewer MACE and better decision-making of downstream investigations and therapeutic interventions.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

symptomatic patients with SCP suspected of obstructive CAD.

referred for CCTA for the assessment of SCP.

≥18 years of age.

signed informed consent.

Disqualifiers

acute coronary syndromes

previous CAD or coronary revascularization

nonsinus rhythm

cardiomyopathy, valvular disease, congenital heart disease or left cardiac insufficiency because of other reasons

Trial population

Patients who were referred for CCTA for the assessment of SCP suspected of CAD.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • CCTA

    Diagnostic test

    All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary.

Treatment groups

50,000 Participants
are divided into 1 treatment group
Group A: CCTA1 intervention

Trial outcomes

Primary outcomes

1

Major adverse cardiovascular events

Cardiac death and myocardial infarction

Time frame
10 years

Secondary outcomes

1

Invasive coronary angiography

Invasive coronary angiography occurred at follow-up after CCTA, attributed to CCTA results or unplanned.

Time frame
10 years
2

Medication prescription

Change for medication prescription of antiplatelet agents, anti-ischemic drugs, lipid-lowering agents, angiotensin-converting enzyme inhibition and so on, attributed to CCTA results or unplanned,

Time frame
10 years
3

Coronary revascularization

PTCA, PCI or CABG occurred at follow-up after CCTA, attributed to CCTA results or unplanned.

Time frame
10 years
4

Number of Participants with Death

Time frame
10 years

Other outcomes

Sponsors and contacts

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