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CEDRN: Opioid Registry

ConditionsOpioid Use DisorderOpioid Abuse or DependenceOpioid WithdrawalPolysubstance Drug Use (Indiscriminate Drug Use)Polysubstance Abuse
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorUniversity of British Columbia

About this trial

Unregulated opioids remain a leading driver of preventable mortality and potential years of life lost in Canada. Emergency departments (EDs)-open 24/7 and frequently accessed by people who use drugs-offer critical opportunities to reverse toxicity, mitigate harm, and initiate treatment. Yet, high quality evidence to guide ED care for patients with opioid poisoning and concomitant opioid dependence or opioid use disorder is limited. The investigators aim to establish a pan Canadian registry of patients presenting to EDs with opioid poisoning to generate timely, practice informing evidence. The investigators will create the Canadian Emergency Department Research Network (CEDRN) Opioid Registry across participating EDs nationwide. Using automated screening of electronic health records (EHRs), the investigators will identify consecutive patients of all ages with suspected or confirmed opioid poisoning at their index ED visit. The project's objectives are to establish a pan-Canadian registry of Emergency Department patients presenting with opioid poisoning, harmonize data collection across participating sites, describe variations in patient characteristics, clinical practice and outcomes, and derive a clinical decision rule to predict the risk of dying within 60 days. The expected outcomes include advancing healthcare delivery, improving patient and provider experiences, and enhancing population health and health system sustainability for individuals with opioid poisoning. This research is crucial for addressing the opioid crisis in Canada and has the potential to significantly impact patient care and outcomes.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Percocet Overdose

Oxycontin Overdose

Oxycodone Overdose

Opioid Overdose or Intoxication

Disqualifiers

None

Trial population

All patients presenting to any one of the Canadian Emergency Department Research Network's emergency department, and meeting the inclusion criteria.

Trial design

Design model

Cohort

Time perspective

Other

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Proportion of patients who received opioid agonist therapy (methadone, buprenorphine/naloxone, extended release buprenorphine injection, slow-release oral morphine).

Number of patients that were administered any of the following types of opioid agonist therapy during their visit to the emergency department.

Time frame
From date of emergency department arrival date until they are discharged from the emergency department (usually within the first 72 hours since arrival time).

Secondary outcomes

Other outcomes

1

Proportion of patients who left against medical advice.

Percentage of patient leave before being formally discharged from the emergency department, or leaving the emergency department without being seen by a physician.

Time frame
From date of emergency department arrival date until date and time of first documented "leaving against medical advice" or "leaving without being seen" or other similar terms in patient's medical chart (within the first 72 hours since arrival).
2

Proportion of patients hospitalized

Whether the patient was admitted to the hospital after their emergency department visit

Time frame
From date of emergency department arrival date until they are discharged from the emergency department (usually within the first 72 hours since arrival time).
3

Proportion of naloxone administration

Was patient administered during their emergency department visit

Time frame
From date of emergency department arrival date until they are discharged from the emergency department (usually within the first 72 hours since arrival time).
4

Proportion of in-hospital mortality

Number of patients who died in the hospital

Time frame
From date of arrival until the date of first hospital documented date of death from any cause (assessed up to 30 days since emergency department arrival).

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of British Columbia

Lead sponsor

Canadian Institutes of Health Research (CIHR)

Collaborator

Source ClinicalTrials.gov
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