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Cell Free DNA in Mature B-cell Lymphoma

ConditionMature B-Cell Lymphoma
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorRuijin Hospital

About this trial

The purpose of this study is to assess whether plasma cell free DNA is an accurate tool that can early and dynamically inform on treatment outcome and an accessible source of tumor DNA to track tumor clonal evolution.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Documented diagnosis of mature B-cell tumor according to WHO 2008 criteria

18 years or older

Disqualifiers

Chemotherapy before

Other tumors

Trial population

Patients with diagnosis of mature B-cell tumor according to WHO 2008 criteria without any previous treatment in Ruijin Hospital would be included.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • peripheral blood collection

    Procedure/Surgery

    peripheral blood collection at treatment start, interm PET/CT, end of treatment PET/CT, one-year and two-year follow-up and or progression or relapse

Treatment groups

320 Participants
are divided into 1 treatment group
Group A: B-cell lymphoma1 intervention

Trial outcomes

Primary outcomes

1

progression free survival

Time frame
2-year

Secondary outcomes

1

overall survival

Time frame
2-year
2

Complete Response rate

Time frame
6 weeks after treatment

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ruijin Hospital

Lead sponsor

Source ClinicalTrials.gov
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