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Cellular and Molecular Analysis of Synovial Tissue of Patients With Arthritis

ConditionsArthritisArthritis, RheumatoidOsteoarthritisSpondyloarthritisSynovitis
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Hospital, Basel, Switzerland

About this trial

This study aims to study the inflammatory response in various forms of arthritis.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age >18 years

Clinically relevant arthritis in one or more joints as assessed by the treating rheumatologist, including RA, SpA, connective tissue disease and OA.

Disqualifiers

Known allergies to local anesthetics

Family history of bleeding, history of increased bleeding tendency or prolonged bleeding, current treatment with oral anticoagulants or platelet aggregation inhibitors; Quick < 65%, international normalised ratio (INR) ≥ 1.3, thrombocyte count < 100'000/μl, activated partial thromboplastin time (aPTT) > 37 sec

Inability or insufficient knowledge of project language to understand the information given in the informed consent form

Trial population

arthritis patients

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Grade of synovitis

assessed by the Krenn score in the hematoxylin and eosin staining (Score 0-3, 0=normal, 3=severe)

Time frame
immediately after collection to study completion, up to 5 years
2

classification pathotypes

immunohistochemical staining with cell type specific markers including CD15, CD68, CD3, CD20, CD138 of the collected tissues from different arthritis subtypes

Time frame
immediately after collection to study completion, up to 5 years
3

comparing transcriptomic signature

single-cell RNA sequencing of collected tissues from different arthritis subtypes to identify disease specific biomarkers.

Time frame
immediately after collection to study completion, up to 5 years

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Hospital, Basel, Switzerland

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: